Near-Infrared Spectroscopy Study for Depression

• Project/Area Number: 15K19736
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Oita University
• Principal Investigator: kanehisa masayuki 大分大学, 医学部, 病院特任助教 (40555190)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 近赤外線照射 / うつ病 / 不安 / 近赤外線 / ラット / 動物モデル

Outline of Final Research Achievements

Pharmacological therapy, psychotherapy, and socio-psychological education are the main treatments for "depression". As a research strategy, we confirm that acute and chronic pulsed near-infrared spectroscopy therapy is effective for "depression" using "rat model of depression". In the results of research, chronic pulse near-infrared spectroscopy therapy significantly suppressed anxiety and depression compared to control and acute administration group. Chronic pulse near-infrared spectroscopy therapy also significantly increased the neogenesis in rat hippocampus.

Research Products

• [Journal Article] Gender differences in automatic thoughts and cortisol and alpha-amylase responses to acute psychosocial stress in patients with obsessive-compulsive personality disorder. (2017)
  • Author(s): Kanehisa M, Kawashima C, Nakanishi M, Okamoto K, Oshita H, Masuda K, Takita F, Izumi T, Inoue A, Ishitobi Y, Higuma H, Ninomiya T, Akiyoshi J.
  • Journal Title: J Affect Disord. Volume: 217 Pages: 1-7
  • DOI: 10.1016/j.jad.2017.03.057
  • Peer Reviewed
• [Journal Article] Different functioning of prefrontal cortex predicts treatment response after a selective serotonin reuptake inhibitor treatment in patients with major depression. (2017)
  • Author(s): Masuda K, Nakanishi M, Okamoto K, Kawashima C, Oshita H, Inoue A, Takita F, Izumi T, Ishitobi Y, Higuma H, Kanehisa M, Ninomiya T, Tanaka Y, Akiyoshi J.
  • Journal Title: J Affect Disord. Volume: 214 Pages: 44-52
  • DOI: 10.1016/j.jad.2017.02.034
  • Peer Reviewed
• [Journal Article] Hyperfunction of left lateral prefrontal cortex and automatic thoughts in social anxiety disorder: A near-infrared spectroscopy study. (2016)
  • Author(s): Kawashima C, Tanaka Y, Inoue A, Nakanishi M, Okamoto K, Maruyama Y, Oshita H, Ishitobi Y, Aizawa S, Masuda K, Higuma H, Kanehisa M, Ninomiya T, Akiyoshi J.
  • Journal Title: J Affect Disord. Volume: 206 Pages: 256-260
  • DOI: 10.1016/j.jad.2016.07.028
  • Peer Reviewed
• [Journal Article] Sex determines cortisol and alpha-amylase responses to acute physical and psychosocial stress in patients with avoidant personality disorder. (2016)
  • Author(s): Tanaka Y, Ishitobi Y, Inoue A, Oshita H, Okamoto K, Kawashima C, Nakanishi M, Aizawa S, Masuda K, Maruyama Y, Higuma H, Kanehisa M, Ninomiya T, Akiyoshi J.
  • Journal Title: Brain Behav. Volume: 6（8） Issue: 8
  • DOI: 10.1002/brb3.506
  • Peer Reviewed / Open Access
• [Journal Article] FKBP5 is associated with amygdala volume in the human brain and mood state: A voxel-based morphometry (VBM) study. (2016)
  • Author(s): Hirakawa H, Akiyoshi J, Muronaga M, Tanaka Y, Ishitobi Y, Inoue A, Oshita H, Aizawa S, Masuda K, Higuma H, Kanehisa M, Ninomiya T, Kawano Y.
  • Journal Title: Int J Psychiatry Clin Pract. Volume: 20（2） Issue: 2 Pages: 106-115
  • DOI: 10.3109/13651501.2016.1144772
  • Peer Reviewed