Does light therapy induce neurogenesis?: FDG-PET stady

• Project/Area Number: 15K19737
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Oita University
• Principal Investigator: KOHNO Kentaro 大分大学, 医学部, 客員研究員 (30555181)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 高照度光療法 / 神経新生 / FDG-PET

Outline of Final Research Achievements

In the present study, not only FDG-PET but also MRI were used to measure morphological changes as well as metabolic changes to determine neurogenesis. Subjects were randomly assigned to blight light therapy and dim light therapy, both of which continued for 4 weeks. As a result, blight light therapy but not dim light therapy significantly increased volume and glucose uptake in the right olfactory bulb. The present findings suggest that bright light therapy for 4 weeks may induce neurogenesis in the right olfactory bulb.

Research Products

• [Journal Article] Postcomparison of [18F]-fluorodeoxyglucose uptake in the brain after short-term bright light exposure and no intervention (2016)
  • Author(s): Kohno K, Terao T, Hatano K, Kodama K, Makino M, Mizokami Y, Kamei K, Sakai A, Shirahama M, Hirakawa H, Kashino G, Matsumoto S, Mori H, Ohashi K, Yano T
  • Journal Title: Acta Psychiatr Scand Volume: 134 Issue: 1 Pages: 65-72
  • DOI: 10.1111/acps.12569
  • Peer Reviewed / Open Access
• [Presentation] 双極性障害と光の影響 (2016)
  • Author(s): 河野 健太郎
  • Organizer: 第26回日本臨床精神神経薬理学会
  • Place of Presentation: ホルトホール大分（大分県・大分市）
  • Year and Date: 2016-11-17
  • Invited
• [Presentation] 高照度光療法と脳画像研究 (2016)
  • Author(s): 平川 博文
  • Organizer: 第26回日本臨床精神神経薬理学会
  • Place of Presentation: ホルトホール大分（大分県・大分市）
  • Year and Date: 2016-11-17