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The analysis of molecular expressions of postmortem brains with schizophrenia: genetic neuropathology

Research Project

Project/Area Number 15K19739
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionFukushima Medical University

Principal Investigator

Kunii Yasuto  福島県立医科大学, 公私立大学の部局等, 准教授 (00511651)

Research Collaborator Yabe Hirooki  福島県立医科大学, 医学部, 教授
Matsumoto Junya  福島県立医科大学, 医学部, 助教
Hino Mizuki  福島県立医科大学, 医学部, 博士研究員
Wada Akira  福島県立医科大学, 医学部, 博士研究員
Niwa Shin-ichi  福島県立医科大学, 会津医療センター, 特任教授
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords統合失調症 / 死後脳研究 / プロテオーム / 遺伝子多型 / 死後脳 / 双極性障害 / ドパミン / DARPP-32 / カルシニューリン / 慢性炎症 / Akt
Outline of Final Research Achievements

We performed genetic neuropathology as follows:1) the examination of protein expressions for members of the Akt signaling pathway using multiplex fluorescent bead based immunoassays in the prefrontal cortex and the nucleus accumbens of postmortem brains from 20 cases with schizophrenia, and association of these expressions with genetic variants; 2) adding 6 bipolar cases, same examination of DARPP-32 and calcineurin; 3) association study between the -141C insertion/deletion polymorphism in the dopamine D2 receptor gene and DARPP-32 expression in the striatum of schizophrenia; 4) the examination of the expressions of molecules involved in immunity and chronic inflammation using the Luminex assay in the superior temporal gyrus of post mortem brains from 60 cases including schizophrenia, and association of these expressions with genetic variants.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (12 results)

All 2018 2017 2016 2015 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 1 results) Presentation (9 results) (of which Int'l Joint Research: 1 results) Remarks (1 results)

  • [Journal Article] Effects of the -141C insertion/deletion polymorphism in the dopamine D2 receptor gene on the dopamine system in the striatum in patients with schizophrenia.2018

    • Author(s)
      Matsumoto J, Nagaoka A, Kunii Y, Miura I, Hino M, Niwa SI, Nawa H, Takahashi H, Kakita A, Yabe H
    • Journal Title

      Psychiatry Res

      Volume: 264 Pages: 116-118

    • DOI

      10.1016/j.psychres.2018.03.029

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreased VEGFR2 expression and increased phosphorylated Akt1 in the prefrontal cortex of individuals with schizophrenia2016

    • Author(s)
      Hino M, Kunii Y, Matsumoto J, Wada A, Nagaoka A, Niwa S, Takahashi H, Kakita A, Akatsu H, Hashizume Y, Yamamoto S, Yabe H
    • Journal Title

      J Psychiatr Res.

      Volume: 82 Pages: 100-108

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 統合失調症脳における慢性炎症関連分子のジェネティックニューロパソロジー2018

    • Author(s)
      21.和田明、國井泰人、日野瑞城、松本純弥、長岡敦子、丹羽真一、竹島明、高橋均、那波宏之、柿田明美、笠井清登、矢部博興
    • Organizer
      第13回日本統合失調症学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 精神疾患死後脳研究の最前線2018

    • Author(s)
      國井泰人、日野瑞城、松本純弥、長岡敦子、丹羽真一、矢部博興
    • Organizer
      第13回日本統合失調症学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 生前登録制度に基づく精神疾患ブレインバンクの実践~当事者と研究者が協働する研究体制とは~2017

    • Author(s)
      國井泰人
    • Organizer
      第113回日本精神神経学会総会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 精神疾患死後脳研究:ジェネティックニューロパソロジー及びリソース利用の有用性2017

    • Author(s)
      國井泰人
    • Organizer
      第39回 日本生物学的精神医学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Alternations of DARPP-32 and Calcineurin protein expressions in the prefrontal cortex and nucleus accumbens of schizophrenia and bipolar disorder and genetic associations with their expressions2016

    • Author(s)
      Yasuto Kunii, Mizuki Hino, Junya Matsumoto, Akira Wada, Atsuko Nagaoka, Shin-ichi Niwa , Yuichi Yokoyama , Hiroyuki Nawa, Hitoshi Takahashi, Akiyoshi Kakita, Hiroyasu Akatsu, Yoshio Hashizume, Sakon Yamamoto, Hirooki Yabe
    • Organizer
      46th Society for Neuroscience Annual Meeting
    • Place of Presentation
      SanDiego,CA,USA
    • Year and Date
      2016-11-15
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 幻聴体験の分子メカニズムを考える-抗EGFR抗体、抗VEGF抗体の投与後に一過性の対話性幻聴を呈した一例2016

    • Author(s)
      長岡敦子 國井泰人 松本純弥 日野瑞城 宮川哲平 飯田聡 山崎繁 矢部博興
    • Organizer
      第38回 日本生物学的精神医学会
    • Place of Presentation
      福岡
    • Year and Date
      2016-09-09
    • Related Report
      2016 Research-status Report
  • [Presentation] 精神疾患死後脳を用いたジェネティックニューロパソロジーの展開2016

    • Author(s)
      國井泰人
    • Organizer
      第38回 日本生物学的精神医学会
    • Place of Presentation
      福岡
    • Year and Date
      2016-09-09
    • Related Report
      2016 Research-status Report
  • [Presentation] 統合失調症患者死後脳前頭前皮質における Akt シグナル伝達系蛋白質群の多項目同時測定2016

    • Author(s)
      日野瑞城, 國井泰人, 松本純弥, 和田明, 長岡敦子, 丹羽真一, 高橋均, 柿田明美, 赤津裕康, 橋詰良夫, 山本孝之, 矢部博興
    • Organizer
      第11回 日本統合失調症学会
    • Place of Presentation
      群馬
    • Year and Date
      2016-03-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 若手研究者育成プログラム・プログレスレポート「精神疾患死後脳を用いたジェネティックニューロパソロジーの展開」2015

    • Author(s)
      國井泰人
    • Organizer
      第37回 日本生物学的精神医学会
    • Place of Presentation
      東京
    • Year and Date
      2015-09-25
    • Related Report
      2015 Research-status Report
  • [Remarks] NPO法人精神疾患死後脳・DNAバンク運営委員会 - 研究事業

    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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