The analysis of molecular expressions of postmortem brains with schizophrenia: genetic neuropathology
Project/Area Number |
15K19739
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Psychiatric science
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Research Institution | Fukushima Medical University |
Principal Investigator |
Kunii Yasuto 福島県立医科大学, 公私立大学の部局等, 准教授 (00511651)
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Research Collaborator |
Yabe Hirooki 福島県立医科大学, 医学部, 教授
Matsumoto Junya 福島県立医科大学, 医学部, 助教
Hino Mizuki 福島県立医科大学, 医学部, 博士研究員
Wada Akira 福島県立医科大学, 医学部, 博士研究員
Niwa Shin-ichi 福島県立医科大学, 会津医療センター, 特任教授
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 統合失調症 / 死後脳研究 / プロテオーム / 遺伝子多型 / 死後脳 / 双極性障害 / ドパミン / DARPP-32 / カルシニューリン / 慢性炎症 / Akt |
Outline of Final Research Achievements |
We performed genetic neuropathology as follows:1) the examination of protein expressions for members of the Akt signaling pathway using multiplex fluorescent bead based immunoassays in the prefrontal cortex and the nucleus accumbens of postmortem brains from 20 cases with schizophrenia, and association of these expressions with genetic variants; 2) adding 6 bipolar cases, same examination of DARPP-32 and calcineurin; 3) association study between the -141C insertion/deletion polymorphism in the dopamine D2 receptor gene and DARPP-32 expression in the striatum of schizophrenia; 4) the examination of the expressions of molecules involved in immunity and chronic inflammation using the Luminex assay in the superior temporal gyrus of post mortem brains from 60 cases including schizophrenia, and association of these expressions with genetic variants.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Decreased VEGFR2 expression and increased phosphorylated Akt1 in the prefrontal cortex of individuals with schizophrenia2016
Author(s)
Hino M, Kunii Y, Matsumoto J, Wada A, Nagaoka A, Niwa S, Takahashi H, Kakita A, Akatsu H, Hashizume Y, Yamamoto S, Yabe H
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Journal Title
J Psychiatr Res.
Volume: 82
Pages: 100-108
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Alternations of DARPP-32 and Calcineurin protein expressions in the prefrontal cortex and nucleus accumbens of schizophrenia and bipolar disorder and genetic associations with their expressions2016
Author(s)
Yasuto Kunii, Mizuki Hino, Junya Matsumoto, Akira Wada, Atsuko Nagaoka, Shin-ichi Niwa , Yuichi Yokoyama , Hiroyuki Nawa, Hitoshi Takahashi, Akiyoshi Kakita, Hiroyasu Akatsu, Yoshio Hashizume, Sakon Yamamoto, Hirooki Yabe
Organizer
46th Society for Neuroscience Annual Meeting
Place of Presentation
SanDiego,CA,USA
Year and Date
2016-11-15
Related Report
Int'l Joint Research
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[Presentation] 統合失調症患者死後脳前頭前皮質における Akt シグナル伝達系蛋白質群の多項目同時測定2016
Author(s)
日野瑞城, 國井泰人, 松本純弥, 和田明, 長岡敦子, 丹羽真一, 高橋均, 柿田明美, 赤津裕康, 橋詰良夫, 山本孝之, 矢部博興
Organizer
第11回 日本統合失調症学会
Place of Presentation
群馬
Year and Date
2016-03-26
Related Report
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