Investigation of the molecular basis for social experience-depencent neural development in prefrotal cortex

Research Project

Project/Area Number	15K19742
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Psychiatric science
Research Institution	Nara Medical University
Principal Investigator	KIMOTO SOHEI 奈良県立医科大学, 医学部, 助教 (00405391)
Project Period (FY)	2015-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000) Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	社会経験 / 前頭前野 / 神経活動依存性 / パルブアルブミン / 認知機能障害 / 社会的隔離 / ネグレクト / 抑制性神経伝達 / 神経活動依存性発現遺伝子
Outline of Final Research Achievements	Social experience during early childhood has been suggested to play crucial roles in brain development and neuronal activity, especially for mental function. To clarify the molecuar basis underlying social experience-dependent neural plasticity, we compared gene expression in medial prefronal cortex between isolate-housing mouse (be housed in isolation from postnatal 21 day to 35 day) and group-housing mouse. We found that the expression of activity-regulated genes that are critical regulators for excitatory and inhibitory balance, and inflammatory-related genes were temporally altered in isolate-housing mouse compared to group-housing mouse. The present data suggest that these molecular changes might contribute to prefrontal dysfunction triggered by social isolation.