Investigation of the molecular basis for social experience-depencent neural development in prefrotal cortex
| Project/Area Number |
15K19742
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Psychiatric science
|
|---|
| Research Institution | Nara Medical University |
|---|
Principal Investigator |
KIMOTO SOHEI 奈良県立医科大学, 医学部, 助教 (00405391)
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 社会経験 / 前頭前野 / 神経活動依存性 / パルブアルブミン / 認知機能障害 / 社会的隔離 / ネグレクト / 抑制性神経伝達 / 神経活動依存性発現遺伝子 |
|---|
| Outline of Final Research Achievements |
Social experience during early childhood has been suggested to play crucial roles in brain development and neuronal activity, especially for mental function. To clarify the molecuar basis underlying social experience-dependent neural plasticity, we compared gene expression in medial prefronal cortex between isolate-housing mouse (be housed in isolation from postnatal 21 day to 35 day) and group-housing mouse. We found that the expression of activity-regulated genes that are critical regulators for excitatory and inhibitory balance, and inflammatory-related genes were temporally altered in isolate-housing mouse compared to group-housing mouse. The present data suggest that these molecular changes might contribute to prefrontal dysfunction triggered by social isolation.
|
Report
(3 results)
Research Products
(2 results)
