Relationship between bipolar disorder and circadian rhythm sleep-wake disorders and effectiveness of chronobiological intervention on the prevention of relapse of mood episodes.
| Project/Area Number |
15K19747
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Kyorin University (2017)
Tokyo Medical University (2015-2016) |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 双極性障害 / 概日リズム睡眠障害 / 再燃 / 時間生物学 / うつ病 / 気分障害 / 概日リズム障害 / 再発予測因子 / 時間生物学的治療 |
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| Outline of Final Research Achievements |
One hundred four BD (41 type I and 63 type II) outpatients and 73 age- and sex-matched major depressive disorder (MDD) outpatients participated in this study. Circadian rhythm sleep-wake disorders (CRSWD) was diagnosed by clinical interview and sleep logs based on the International Classification of Sleep Disorders, third edition. As a result, the rate of CRSWD in BD subjects was significantly higher than that in MDD subjects. A multiple logistic regression analysis revealed that comorbid CRSWD was significantly associated with BD in patients with remitted mood disorders.
Of the total 104 BD subjects, 51 (49.0%) subjects experienced relapse during the 48-week follow-up period. Multivariate Cox hazard regression analyses revealed that two or more previous mood episodes within the past year and comorbidity of CRSWD were significantly associated with the time to relapse of mood episodes.
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Report
(4 results)
Research Products
(9 results)
