Resilience and relationship to a biological background in individuals with an at risk mental state
| Project/Area Number |
15K19749
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Toho University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 精神病発症危険状態 / ARMS / 統合失調症 / レジリエンス / MRI / 探索眼球運動 / 線条体 / 脳梁 / 精神病発症閾値下の精神病症状 / SIPS/SOPS / 早期介入 / 閾値下の精神病症状 / 精神病閾値下の精神病症状 / 脳・神経 / resilience / 脳MRI |
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| Outline of Final Research Achievements |
Recent studies have revealed that several psychotic symptom changes observed in the ‘at risk mental state’ (ARMS) are associated with changes in the neural network in the brain. We investigated if structural changes in the corpus callosum（CC）and striatum those are supposed as a parts of brain networks are associated with recovery of sub-threshold psychotic symptoms in subjects with an ARMS who did not develop psychosis (ARMS-N).
For the ARMS-N subjects, improvement in negative symptoms significantly correlated with an increase in the volume of the central CC at follow-up. While, improvement in sub-threshold positive symptoms significantly correlated with an increase in volume in the right accumbens at follow up. These finding may suggest that a neurobiological‘resilience’is associated with symptom recovery.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、ARMS群のうち経過観察の後も精神病発症に至らないため、これまで偽陽性群とも呼ばれてきたARMS非発症群であったとしても脳内の広範なネットワークを担う脳梁や線条体で病的変化が生じている可能性を示した。一方で精神病症状の発現が阻止され改善する過程に同部位の体積変化などの生物学的変化が寄与する可能性を示した。これらの機序の解明はARMSにおける回復、いわゆるレジリエンスの機序の究明への端緒となり、精神病の発症を阻止するための包括的な治療戦略の構築に資するものである。
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Report
(6 results)
Research Products
(21 results)
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[Presentation] Symptom recovery and relationship to structure of corpus callosum in individuals with an ‘At risk mental State’ (ARMS): a longitudinal study.2016
Author(s)
Naoyuki Katagiri, Takahiro Nemoto, Naohisa Tsujino, Junichi Saito, Masaaki Hori, Taiju Yamaguchi, Tomoyuki Funatogawa, Hiroshi Matsumoto, Yoko Baba, Yusuke Shido, Takashi Uchino, Masafumi Mizuno
Organizer
IEPA 10th International Conference on Early Intervention in Mental Health
Place of Presentation
Milan, Italy
Year and Date
2016-10-20
Related Report
Int'l Joint Research
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