| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Recent studies have revealed that several psychotic symptom changes observed in the ‘at risk mental state’ (ARMS) are associated with changes in the neural network in the brain. We investigated if structural changes in the corpus callosum（CC）and striatum those are supposed as a parts of brain networks are associated with recovery of sub-threshold psychotic symptoms in subjects with an ARMS who did not develop psychosis (ARMS-N).
For the ARMS-N subjects, improvement in negative symptoms significantly correlated with an increase in the volume of the central CC at follow-up. While, improvement in sub-threshold positive symptoms significantly correlated with an increase in volume in the right accumbens at follow up. These finding may suggest that a neurobiological‘resilience’is associated with symptom recovery.
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