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Lithium for mild-to-moderate Alzheimer's disease: A randomized double-blind, placebo-controlled study

Research Project

Project/Area Number 15K19750
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionFujita Health University

Principal Investigator

Matsunaga Shinji  藤田保健衛生大学, 医学部, 講師 (30726641)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsアルツハイマー型認知症 / リチウム / ランダム化比較試験 / Alzheimer's disease / Alzheimer disease / Lithium / アルツハイマー病
Outline of Final Research Achievements

Previous studies suggest that lithium inhibits the progression of cognitive dysfunction of Alzheimer disease. In 2015, we conducted a systematic review and a meta-analysis of randomized controlled trials and reported that lithium may have the effect of inhibiting the progress of cognitive dysfunction on Alzheimer disease. Based on these results, we started a double-blind, placebo-controlled, randomized controlled trial on the efficacy and safety of lithium on Alzheimer disease for Japanese population. Currently, this trial is recruiting subjects.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (2 results)

All 2015

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Lithium as a Treatment for Alzheimer's Disease: A Systematic Review and Meta-Analysis2015

    • Author(s)
      Shinji Matsunaga; Taro Kishi; Peter Annas; Hans Basun; Harald Hampel ; Nakao Iwata
    • Journal Title

      Journal of Alzheimer's disease

      Volume: 48(2) Issue: 2 Pages: 403-410

    • DOI

      10.3233/jad-150437

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Lithium as a Treatment for Alzheimer's Disease: A Systematic Review and Meta-Analysis2015

    • Author(s)
      Shinji Matsunaga; Taro Kishi; Peter Annas; Hans Basun; Harald Hampel; Nakao Iwata
    • Organizer
      Alzheimer's Association International Conference 2015
    • Place of Presentation
      Washington
    • Year and Date
      2015-07-24
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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