Biochemical dissection of sphingolipids in the pathophysiology of psychiatric illnesses
Project/Area Number |
15K19754
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Psychiatric science
|
Research Institution | Institute of Physical and Chemical Research |
Principal Investigator |
ESAKI Kayoko 国立研究開発法人理化学研究所, 脳科学総合研究センター, 基礎科学特別研究員 (20744874)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
Keywords | 精神疾患 / スフィンゴ脂質 / 脂質生化学 / セリン |
Outline of Final Research Achievements |
The disease mechanisms underlying psychiatric disorders remain largely undetermined. Schizophrenia is a mental illness featuring three major symptomatic domains: positive symptoms, negative symptoms and cognitive deficits. It presents with a prevalence of approximately 1% worldwide, making it a relatively common disease. Increasing clinical evidence indicates that sphingolipids are implicated in the pathogenesis of schizophrenia. To figure out the involvement of sphingolipids in schizophrenia, I analyzed sphingolipids of postmortem brains from schizophrenia patients. Our mass spectrometry-based lipidomic approach demonstrated a change of sphingolipids in the corpus callosum of schizophrenia patients. Furthermore, the gene expression level of sphingolipid-metabolic enzymes and sphingolipid receptors altered in schizophrenia. From these findings, it is thought that dysregulation of sphingolipid receptor functions causes in the brain of schizophrenia patients.
|
Report
(4 results)
Research Products
(13 results)
-
[Journal Article] Adaptive response to L-serine deficiency is mediated by p38 MAPK activation via 1-deoxysphinganine in normal fibroblasts2016
Author(s)
Tomoko Sayano, Yuki Kawano, Wataru Kusada, Yashiho Arimoto, Kayoko Esaki, Momoko Hamano, Miyako Udono, Yoshinori Katakura, Takuya Ogawa, Hisanori Kato, Yoshio Hirabayashi, Shigeki Furuya
-
Journal Title
FEBS Open Bio
Volume: 6
Issue: 4
Pages: 303-316
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-