The mechanism of tau accumulation in the striatum of tauopathy
| Project/Area Number |
15K19757
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Tokyo Metropolitan Institute of Medical Science |
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Principal Investigator |
KAWAKAMI Ito 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 研究員 (60748838)
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| Co-Investigator(Renkei-kenkyūsha) |
AKIYAMA Haruhiko 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 研究員 (20231839)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | タウ / 神経原線維変化 / アルツハイマー病 / 神経原線維変化型老年期認知症 / 伝播 / 線条体 / 側坐核 / 神経原線維型認知症 |
|---|
| Outline of Final Research Achievements |
Tangle-predominant dementia (TPD) is characterized neuropathologically by numerous neurofibrillary tangles in the limbic areas with no or occasional senile plaques throughout the brain. I investigated the brain tissues from Alzheimer's disease（AD）, TPD and normal aged cases immunohistochemically. I used several antibodies including anti-tau antibodies in the experiments. As the results, in the striatum of TPD cases, tau deposit were only found in the region which receives fibers from hippocampus /limbic area. Otherwise, in the area of AD cases, the regions receiving fibers from neocortex show tau deposit besides the former region. This may support the idea that abnormal tau aggregation propagates via neural circuits.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Chorea as a clinical feature of the basophilic inclusion body disease subtype of fused-in-sarcoma-associated frontotemporal lobar degeneration.2016
Author(s)
Kawakami I, Kobayashi Z, Arai T, Yokota O, Nonaka T, Aoki N, Niizato K, Oshima K, Higashi S, Katsuse O, Hosokawa M, Hasegawa M, Akiyama H.
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Journal Title
Acta Neuropathol Commun
Volume: 4
Issue: 1
Pages: 36-36
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] A family with hereditary diffuse leukoencephalopathy with spheroids caused by a novel c.2442+2T>C mutation in the CSF1R gene.2016
Author(s)
Kawakami I, Iseki E, Kasanuki K, Minegishi M, Sato K, Hino H, Shibuya K, Fujisawa K, Higashi S, Akiyama H, Furuta A, Takanashi M, Li Y, Hattori N, Mitsuyama Y, Arai H.
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Journal Title
Journal of Neuroogicall Science
Volume: 15;367
Pages: 349-55
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Chorea as a clinical feature of BIBD subtype of FTLD-FUS2016
Author(s)
Ito Kawakami, Zen Kobayashi, Tetsuaki Arai, Osamu Yokota, Takashi Nonaka, Kazuhiro Niizato, Kenichi Oshima, Shinji Higashi, Masato Hosokawa, Masato Hasegawa and Haruhiko Akiyama
Organizer
10th International Conference on Frontotemporal Dementia
Place of Presentation
ミュンヘン（ドイツ）
Year and Date
2016-08-31
Related Report
Int'l Joint Research
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[Presentation] Chorea as a clinical feature of BIBD subtype of FTLD-FUS2016
Author(s)
Ito Kawakami, Zen Kobayashi, Tetsuaki Arai, Osamu Yokota, Takashi Nonaka, Naoya Aoki, Kazuhiro Niizato, Kenichi Oshima, Shinji Higashi, Omi Katsuse, Masato Hosokawa, Masato Hasegawa and Haruhiko Akiyama
Organizer
10th International Conference on Frontotemporal Dementias
Place of Presentation
ミュンヘン(ドイツ)
Year and Date
2016-08-31
Related Report
Int'l Joint Research
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[Presentation] 非定型タウオパチーの二剖検例2015
Author(s)
河上 緒, 新井 哲明, 池田 研二, 大島 健一, 新里 和弘, 細川 雅人, 長谷川 成人, 秋山 治彦
Organizer
第56回日本神経病理学会総会学術研究会
Place of Presentation
九州大学医学部百年講堂(福岡県福岡市)
Year and Date
2015-06-03
Related Report
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