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Development of the prognosis prediction method using treatment response mapping obtained by MRI for head and neck squamous cell carcinoma patients

Research Project

Project/Area Number 15K19761
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionHokkaido University

Principal Investigator

Fujima Noriyuki  北海道大学, 大学病院, 助教 (80431360)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords画像診断 / 頭頚部癌 / MRI / 癌 / 頭頸部扁平上皮癌
Outline of Final Research Achievements

We have developed the tumor growth rate reflected mapping using the improved diffusion weighted imaging with original post-processing technique. This mapping was validated by comparing the directly measured tumor growth rate obtained by the short-term follow-up. We also developed the tumor blood flow mapping using arterial spin labeling technique with our original advanced signal processing technique. This mapping was validated by comparing the prefusion related parameters obtained by dynamic contrast enhanced perfusion technique. By using these two parameters of tumor growth rate and tumor blood flow mapping, prediction of the treatment outcome in patients with head and neck squamous cell carcinoma has been successfully performed with a certain threshold value. By integrating these two mapping, we have developed the treatment response mapping with the mixture of the tumor growth rate and tumor blood flow.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (11 results)

All 2018 2017 2016 2015

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Open Access: 2 results,  Acknowledgement Compliant: 4 results) Presentation (2 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Utility of a Hybrid IVIM-DKI Model to Predict the Development of Distant Metastasis in Head and Neck Squamous Cell Carcinoma Patients2018

    • Author(s)
      Fujima N, Sakashita T, Homma A, Yoshida D, Kudo K, Shirato H.
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 17 Issue: 1 Pages: 21-27

    • DOI

      10.2463/mrms.mp.2016-0136

    • NAID

      130006306824

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Non-invasive prediction of the tumor growth rate using advanced diffusion models in head and neck squamous cell carcinoma patients.2017

    • Author(s)
      Fujima N, Sakashita T, Homma A, Harada T, Shimizu Y, Tha KK, Kudo K, Shirato H.
    • Journal Title

      Oncotarget

      Volume: 8 Issue: 20 Pages: 33631-33643

    • DOI

      10.18632/oncotarget.16851

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Residual tumour detection in post-treatment granulation tissue by using advanced diffusion models in head and neck squamous cell carcinoma patients.2017

    • Author(s)
      Fujima N, Yoshida D, Sakashita T, Homma A, Kudo K, Shirato H
    • Journal Title

      Eur J Radiol

      Volume: 90 Pages: 14-19

    • DOI

      10.1016/j.ejrad.2017.02.025

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prediction of the treatment outcome using intravoxel incoherent motion and diffusional kurtosis imaging in nasal or sinonasal squamous cell carcinoma patients2017

    • Author(s)
      Fujima N, Yoshida D, Sakashita T, Homma A, Tsukahara A, Shimizu Y, Tha KK, Kudo K, Shirato H
    • Journal Title

      European Radiology

      Volume: 27(3) Issue: 3 Pages: 956-965

    • DOI

      10.1007/s00330-016-4440-1

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Advanced diffusion models in head and neck squamous cell carcinoma patients: Goodness of fit, relationships among diffusion parameters and comparison with dynamic contrast-enhanced perfusion2017

    • Author(s)
      Fujima N, Sakashita T, Homma A, Shimizu Y, Yoshida A, Harada T, Tha KK, Kudo K, Shirato H.
    • Journal Title

      Magnetic Resonance Imaging

      Volume: 36 Pages: 16-23

    • DOI

      10.1016/j.mri.2016.10.024

    • NAID

      120006382282

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Glucose Metabolism and Its Complicated Relationship with Tumor Growth and Perfusion in Head and Neck Squamous Cell Carcinoma.2016

    • Author(s)
      Fujima N, Sakashita T, Homma A, Hirata K, Shiga T, Kudo K, Shirato H
    • Journal Title

      Plos One

      Volume: ー Issue: 11 Pages: e0166236-e0166236

    • DOI

      10.1371/journal.pone.0166236

    • NAID

      120005905627

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Usefulness of Pseudocontinuous Arterial Spin-Labeling for the Assessment of Patients with Head and Neck Squamous Cell Carcinoma by Measuring Tumor Blood Flow in the Pretreatment and Early Treatment Period2016

    • Author(s)
      Fujima N, Yoshida D, Sakashita T, Homma A, Tsukahara A, Tha KK, Kudo K, Shirato H
    • Journal Title

      American journal of neuroradiology

      Volume: 37(2) Issue: 2 Pages: 342-8

    • DOI

      10.3174/ajnr.a4513

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Differentiation of squamous cell carcinoma and inverted papilloma using non-invasive MR perfusion imaging2015

    • Author(s)
      Fujima N, Nakamaru Y, Sakashita T, Homma A, Tsukahara A, Kudo K, Shirato H
    • Journal Title

      Dento maxillo facial Radiology

      Volume: 44(9) Issue: 9 Pages: 74-82

    • DOI

      10.1259/dmfr.20150074

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Diagnostic value of tumor blood flow and its histogram analysis obtained with pCASL to differentiate sinonasal malignant lymphoma from squamous cell carcinoma2015

    • Author(s)
      Fujima N, Kameda H, Tsukahara A, Yoshida D, Sakashita T, Homma A, Tha KK, Kudo K, Shirato H
    • Journal Title

      European journal of radiology

      Volume: 84(11) Issue: 11 Pages: 2187-93

    • DOI

      10.1016/j.ejrad.2015.07.026

    • NAID

      120005853059

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] Residual tumour detection in post-treatment granulation tissue by using advanced diffusion models in head and neck squamous cell carcinoma patients2017

    • Author(s)
      Fujima N, Yoshida D, Sakashita T,Homma A, Kudo K
    • Organizer
      ISMRM 25th Annual meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of the water permeability using DW-ASL; assessment of the ischemic lesion in the brain2017

    • Author(s)
      Fujima N, Okuaki T, Aoike S, Aoike T, Sugimori H, Kudo K
    • Organizer
      ISMRM 25th Annual meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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