| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
We applied a surface model using 3D treatment planning for Carbon-ion radiotherapy and Intensity-modulated radiation therapy of head and neck cancer. We analyzed the maximum and mean dose and dose-volume histogram associated with acute radiation mucositis in head and neck cancers patients. The location of the acute radiation mucositis coincided with the high-dose anatomical region in the Oral mucosal dose surface model. Using this model, there was a clear dose-response relationship between maximum and mean dose and acute radiation mucositis grade, as assessed by the RTOG criteria.
In addition, this model may facilitate early support for performing oral care when related toxicity can be predicted. This model is a useful tool for sharing information regarding radiation mucositis with both the entire medical staff and the patient, since it is a 3D image that is easy to interpret and predicts which patients are at a high risk for radiation mucositis in corresponding anatomical sub-regions.
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