Combination with carbon ion radiotherapy and chemotherapy or non small cell lung cancer
| Project/Area Number |
15K19770
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Gunma University |
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Principal Investigator |
Kubo Nobuteru 群馬大学, 医学部附属病院, 助教 (30727813)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 重粒子 / 炭素イオン線 / 非小細胞肺癌 / 化学放射線療法 / 肺癌 / 重粒子線治療 / 炭素イオン線治療 / 重粒子線 / カルボプラチン / パクリタキセル |
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| Outline of Final Research Achievements |
Using the non-small cell lung cancer cell lines, the sensitizing effect of carbon ion beam and anticancer agent was investigated. As a result of in vitro experiments, it was confirmed that sensitizing effect was almost equal or a little lower than that of X rays. This suggested the combination with carbon ion radiotherapy and anticancer drugs (carboplatin and paclitaxel) for non-small cell lung cancer are useful. As a clinical approach, we studied the difference in dose distribution between X-rays and carbon ion beams for locally advanced lung cancer. Compared with X-ray, carbon ion radiotherapy provides a more homogeneous target dose and a lower dose to organs at risk than X-ray radiotherapy for Stage IIIA non-small cell lung cancer.
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Report
(4 results)
Research Products
(1 results)
