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Network Analysis of MRI for the Diagnosis of Epilepsy

Research Project

Project/Area Number 15K19773
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionThe University of Tokyo

Principal Investigator

Amemiya Shiori  東京大学, 医学部附属病院, 助教 (90631135)

Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsfMRI / network / ネットワーク / てんかん
Outline of Final Research Achievements

The study aims to develop fMRI analyses to identify disease-specific abnormal neural activity. First, we compared the spatiotemporal pattern of BOLD signal and that of the hemodynamics and showed that there might be multiple global neural activities besides local synchronous activity (i.e. so-called resting-state network: RSN) (Amemiya et al. Neuroimage 2016). In order to understand the basis of the interaction between networks, we further try to develop an analysis that enables the separate identification of both components. We have also developed a method for detecting spatiotemporal asymmetry of the spontaneous nerve activity and reported it together with the usefulness of the integrated multi-echo denoising strategy (Amemiya et al. MRM 2019).

Academic Significance and Societal Importance of the Research Achievements

fMRIを用いて疾患特異的な異常神経活動を同定するためには、非神経活動成分の正確な同定が必要となり、特に動態解析における重要性が高い。今回の研究では、神経活動の時空間解析に血行動態解析を合わせること、またtemporal ICAの応用により全脳性神経活動の伝播経路を推計する事を可能とした。安静時fMRIが主に対象とするresting-state networks(RSN)活動は自発性神経活動全体から見ればごく一部の現象であり、ネットワーク間相互作用等を理解する上でも、広汎性活動性の評価は重要性が高い。但し解析難易度の高さから、これまで試みられた事が少ない領域であり、今後の応用拡大が期待される。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (5 results)

All 2019 2018 2016 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Integrated multi-echo denoising strategy improves identification of inherent language laterality2018

    • Author(s)
      Shoiri Amemiya, Hiroshi Yamashita, Hidemasa Takao, Osamu Abe
    • Journal Title

      Magnetic Resonance in Medicine

      Volume: 81 Issue: 5 Pages: 3262-3271

    • DOI

      10.1002/mrm.27620

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Global and structured waves of rs-fMRI signal identified as putative propagation of spontaneous neural activity2016

    • Author(s)
      Shiori Amemiya, Hidemasa Takao, Shohei Hanaoka, Kuni Ohtomo
    • Journal Title

      NeuroImage

      Volume: 133 Pages: 331-340

    • DOI

      10.1016/j.neuroimage.2016.03.033

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] Integrated multi-echo denoising strategy improves language mapping with resting-state fMRI2019

    • Author(s)
      Shoiori Amemiya
    • Organizer
      ECR 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 統合的マルチエコー安静時fMRI 解析法は内因性神経活動の半球優位性評価を改善する2018

    • Author(s)
      雨宮 史織
    • Organizer
      第54回日本医学放射線学会秋季臨床大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] rs-fMRI temporal lag analysis reveals structured propagation of spontaneous2015

    • Author(s)
      雨宮史織, 高尾英正, 花岡昇平, 大友邦
    • Organizer
      第43回日本磁気共鳴医学会大会
    • Place of Presentation
      東京ドームホテル(東京都、文京区)
    • Year and Date
      2015-09-10
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2020-03-30  

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