The investigation of imaging biomarkers predicting hepatic stem cell feature and epithelial-mesenchymal transition feature in hepatocellular carcinoma
| Project/Area Number |
15K19780
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 肝幹細胞 / 上皮間葉移行(EMT) / 肝細胞癌 / 画像バイオマーカー / EMT / 上皮間葉移行 / 画像 / EpCAM |
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| Outline of Final Research Achievements |
Epithelial cell adhesion molecule (EpCAM) positive hepatocellular carcinomas (HCC) having hepatic stem cell feature showed significantly higher incidence of imaging features including a heterogeneous arterial enhancement and internal no enhancement portion on dynamic CT study, lower apparent diffusion coefficient (ADC) value on diffusion weighted image, and non-smooth margin on hepatobiliary phase (HB phse) of Gd-EOB-DTPA enhanced MRI (EOB-MRI). These imaging findings are useful for predicting EpCAM positive hepatocellular carcinoma and are thought to contribute to future personalized medicine.
Regarding epithelial-mesenchymal transition (EMT) positive HCCs, there was no significant imaging features that can predict epithelial-mesenchymal transition (EMT) positive HCCs. However enhancement ratio of HB phase of EOB-MRI tended to be lower in EMT positive HCCs compared with EMT negative HCCs.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Gadoxetic acid-enhanced magnetic resonance imaging reflects co-activation of β-catenin and hepatocyte nuclear factor 4α in hepatocellular carcinoma.2018
Author(s)
Kitao A, Matsui O, Yoneda N, Kozaka K, Kobayashi S, Koda W, Minami T, Inoue D, Yoshida K, Yamashita T, Yamashita T, Kaneko S, Takamura H, Ohta T, Ikeda H, Sato Y, Nakanuma Y, Harada K, Kita R, Gabata T.
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Journal Title
Hepatology Research
Volume: 48
Issue: 2
Pages: 205-216
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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