| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Epithelial cell adhesion molecule (EpCAM) positive hepatocellular carcinomas (HCC) having hepatic stem cell feature showed significantly higher incidence of imaging features including a heterogeneous arterial enhancement and internal no enhancement portion on dynamic CT study, lower apparent diffusion coefficient (ADC) value on diffusion weighted image, and non-smooth margin on hepatobiliary phase (HB phse) of Gd-EOB-DTPA enhanced MRI (EOB-MRI). These imaging findings are useful for predicting EpCAM positive hepatocellular carcinoma and are thought to contribute to future personalized medicine.
Regarding epithelial-mesenchymal transition (EMT) positive HCCs, there was no significant imaging features that can predict epithelial-mesenchymal transition (EMT) positive HCCs. However enhancement ratio of HB phase of EOB-MRI tended to be lower in EMT positive HCCs compared with EMT negative HCCs.
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