Quantitative measurement of optical parameters by time-resolved near-infrared spectroscopy in breast cancer
| Project/Area Number |
15K19781
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Keywords | 近赤外光 / 乳癌 / 光源検出器間距離 / 腫瘍サイズ / 腫瘍の深さ / dual energy CT / ヘモグロビン濃度 |
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| Outline of Final Research Achievements |
Hemoglobin concentration and tissue oxygen saturation (SO2) of breast cancer can be measured noninvasively by near-infrared time-resolved spectroscopy system (TRS). The purpose of this study was to evaluate the effects of the thickness and depth of tumors on hemoglobin measurements in breast cancer by TRS, and to demonstrate SO2 and reduced scattering coefficient (μs’) in breast tissue and breast cancer in relation to the skin-to-chest wall distance. There was a positive correlation between total hemoglobin concentration (tHb) and tumor thickness, and a negative correlation between tHb and tumor depth. SO2 in breast tissue decreased when the skin-to-chest wall distance decreased, and SO2 in tumors tended to be lower than in breast tissue. In breast tissue, there was a negative correlation between μs’ and the skin-to-chest wall distance, and μs’ in tumors was higher than in breast tissue.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Near-Infrared Diffuse Optical Imaging for Early Prediction of Breast Cancer Response to Neoadjuvant Chemotherapy: A Comparative Study Using 18F-FDG PET/CT.2016
Author(s)
Ueda S, Yoshizawa N, Shigekawa T, Takeuchi H, Ogura H, Osaki A, Saeki T, Ueda Y, Yamane T, Kuji I, Sakahara H.
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Journal Title
J Nucl Med
Volume: 57
Issue: 8
Pages: 1189-1195
DOI
Related Report
Peer Reviewed
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