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PET imaging of astrocytes during the development of Alzheimer's disease

Research Project

Project/Area Number 15K19787
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionOsaka University

Principal Investigator

Watabe Tadashi  大阪大学, 医学系研究科, 助教 (90648932)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsアストロサイト / PET / フルオロクエン酸 / Acetate / アルツハイマー病モデル / Alzheimer病 / PETイメージング
Outline of Final Research Achievements

Fluorocitrate (FC) is a metabolic inhibitor of tricarbonic acid (TCA) cycle specifically in astrocyte and acetate uptake is a marker of astrocytic TCA cycle activity in brain. Oxygen-15 (15O) PET is the reference standard for quantitative assessment of cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO2). The primary purpose of this study was to evaluate whether the inhibition of astrocytic TCA cycle metabolism by FC will affect the oxygen metabolism in the rat brain. There were no significant differences between the ipsilateral and contralateral striatum in each parameter using the 15O-gas PET. In 14C-acetate autoradiography results, there is significant inhibition in the astrocyte metabolism after FC injection in the ipsilateral striatum.Regional cerebral oxygen consumption as well as hemodynamic parameters was maintained against the inhibition of astrocytic TCA cycle metabolism in the rat brain.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (3 results)

All 2018 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (1 results) (of which Int'l Joint Research: 1 results) Book (1 results)

  • [Journal Article] Oxygen-15 labeled CO2, O2, and CO PET in small animals: evaluation using a 3D-mode microPET scanner and impact of reconstruction algorithms.2017

    • Author(s)
      Horitsugi G, Watabe T, Kanai Y, Ikeda H, Kato H, Naka S, Ishibashi M, Matsunaga K, Isohashi K, Shimosegawa E, Hatazawa J.
    • Journal Title

      EJNMMI Res

      Volume: 7 Issue: 1 Pages: 91-91

    • DOI

      10.1186/s13550-017-0335-7

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Preserved Cerebral Oxygen Metabolism against Astrocytic Dysfunction: A Combination Study of O-15 Gas PET with C-14 Acetate Autoradiography2018

    • Author(s)
      Carla Mari Macaisa; Tadashi Watabe; Yuwei Liu; Victor Romanov; Yasukazu Kanai; Genki Horitsugi; Hiroki Kato; Eku Shimosegawa; Jun Hatazawa
    • Organizer
      SNMMI2018(米国核医学会)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Book] BIO Clinica2017

    • Author(s)
      渡部直史
    • Total Pages
      5
    • Publisher
      (株)北隆館
    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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