Research Project
Grant-in-Aid for Young Scientists (B)
Fluorocitrate (FC) is a metabolic inhibitor of tricarbonic acid (TCA) cycle specifically in astrocyte and acetate uptake is a marker of astrocytic TCA cycle activity in brain. Oxygen-15 (15O) PET is the reference standard for quantitative assessment of cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO2). The primary purpose of this study was to evaluate whether the inhibition of astrocytic TCA cycle metabolism by FC will affect the oxygen metabolism in the rat brain. There were no significant differences between the ipsilateral and contralateral striatum in each parameter using the 15O-gas PET. In 14C-acetate autoradiography results, there is significant inhibition in the astrocyte metabolism after FC injection in the ipsilateral striatum.Regional cerebral oxygen consumption as well as hemodynamic parameters was maintained against the inhibition of astrocytic TCA cycle metabolism in the rat brain.
All 2018 2017
All Journal Article (1 results) (of which Peer Reviewed: 1 results, Open Access: 1 results) Presentation (1 results) (of which Int'l Joint Research: 1 results) Book (1 results)
EJNMMI Res
Volume: 7 Issue: 1 Pages: 91-91
10.1186/s13550-017-0335-7
