Production of Molybdenum-99 by Accelerator and Purification of Technetium-99m

• Project/Area Number: 15K19789
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Tohoku University (2016); Osaka University (2015)
• Principal Investigator: Ikeda Hayato 東北大学, サイクロトロン・ラジオアイソトープセンター, 助教 (30649083)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: テクネチウム-99m / モリブデン99 / 加速器 / 溶媒抽出 / モリブデン-99 / 核医学 / 放射性医薬品製造

Outline of Final Research Achievements

In this work, I searched the organic solvent for effective extraction Tc-99m produced by accelerator from Mo aqueous solution. I used methyl ethyl ketone (MEK), methyl isobutyl ketone (MIBK), diethyl ketone (DEK), and other some solvents. I produced the Mo solution and Mo solution doped commercial Tc-99m, which similar to Mo target dissolved solution.
High quantity of Tc-99m could be extracted independent on volume of organic layer with three ketones. However, in the case of some other solvents, The quantity of extraction of Tc-99m was proportional to a volume, and its quantity was little. In addition, the contamination of the Mo was unavoidable with the ketones. And it found that alumina column treatment could not to be omitted.

Research Products

• [Presentation] Extraction of technetium-99m by some organic solvents from macro scale molybdenum solution. (2016)
  • Author(s): Hayato Ikeda, Yoshihiko Hayashi, Naruto Takahashi, Kozi Nakai, Atsushi Shinohara, Tadashi Watabe, Yasukazu Kanai, Hiroki Kato, Eku Shimosegawa, Jun Hatazawa
  • Organizer: SNMMI 2016 Annual Meeting
  • Place of Presentation: San Diego, California
  • Year and Date: 2016-06-11
  • Int'l Joint Research