Development of a new treatment method using Platelet-Rich Plasma for radiation adverse events

• Project/Area Number: 15K19793
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Kobe University
• Principal Investigator: Matsuo Yoshiro 神戸大学, 医学部附属病院, 医員 (90749201)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: 放射線脱毛 / 多血小板血漿

Outline of Final Research Achievements

To radiation induced hair loss model rats, Platelet-Rich Plasma (PRP) was administered while changing radiation dose, administration method, and administration timing. A confirmation experiment was performed with the combination which seemed to be the most effective, and after macroscopic examination until 7 weeks after the irradiation, tissue collection and examination using a stained tissue were performed.
In the macroscopic evaluation, the degree of radiation-induced hair loss was reduced in the group injected with PRP intradermally for the group not given any dose to the irradiation and the group injected with the saline intradermally. In the histological examination using tissues collected 7 weeks after irradiation, the number of hair follicles was higher in the group injected intradermally with PRP than in other groups. PRP has been shown to be effective against radiation-induced hair loss.

Research Products

• [Journal Article] Efficacy of Stereotactic Body Radiotherapy for Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis / Inferior Vena Cava Tumor Thrombosis: Evaluation by Comparison with Conventional Three-Dimensional Conformal Radiotherapy, (2016)
  • Author(s): Yoshiro Matsuo, Kenji Yoshida, Hideki, Nishimura, Yasuo Ejima, Daisuke Miyawaki, Haruka Uezono, Takeaki Ishihara, Hiroshi Mayahara, Takumi Fukumoto, Yonson Ku, Masato Yamaguchi, Koji Sugimoto, and Ryohei Sasaki,
  • Journal Title: J Radiat Res Volume: 57(5) Issue: 5 Pages: 512-523
  • DOI: 10.1093/jrr/rrw028
  • Peer Reviewed / Open Access
• [Presentation] Treatment outcome of definitive radiotherapy for primary malignant tumor of nasal cavity (2016)
  • Author(s): Ryo Nishikawa, Kenji Yoshida, Daisuke Miyawaki, Takeaki Ishihara, Yuko Inoue, Yoshiro Matsuo, Nor Shazrina, Yasuo Ejima, Miki Saito, Kenichi Nibu, Ryohei Sasaki.
  • Organizer: The 29th Annual Meeting of the Japanese Society for Radiation Oncology
  • Place of Presentation: Kyoto Japan
  • Year and Date: 2016-11-25
• [Presentation] A case of uterine cervical cancer presenting with dermatomyositis as a paraneoplastic syndrome (2016)
  • Author(s): Kaori Sasaki, Kenji Yoshida, Daisuke Miyawaki, Yoshiro Matsuo, Ryo Nishikawa, Takeaki Ishihara, Yasuo Ejima, Hiroaki Akasaka, Yoshiya Miyawaki, Takehiro Ueda, Ryohei Sasaki
  • Organizer: The 29th Annual Meeting of the Japanese Society for Radiation Oncology
  • Place of Presentation: Kyoto Japan
  • Year and Date: 2016-11-25
• [Presentation] Experience of IGABT using interstitial needles for locally advanced gynecologic malignancies (2016)
  • Author(s): Kenji Yoshida, Ryo Nishikawa, Daisuek Miyawaki, Mayumi Omoteda, Katsusuke Kyotani, Hiroaki Akasaka, Kaori Sasaki, Yoshiro Matsuo, Yasuhiko Ebina, Hideto Yamada, Ryohei Sasaki
  • Organizer: The 29th Annual Meeting of the Japanese Society for Radiation Oncology
  • Place of Presentation: Kyoto Japan
  • Year and Date: 2016-11-25
• [Presentation] Assessment of the threshold dose for radiation fibrosis in thoracic esophageal cancer patients (2016)
  • Author(s): Yasuo Ejima, Kenji Yoshida, Daisuke Miyawaki, Takeaki Ishihara, Ryo Nishikawa, Hiroki Kawaguchi, Yoshiro Matsuo, Atsuki Ikeda, Masanori Toyoda, Tetsu Nakamura, Ryohei Sasaki
  • Organizer: The 1st Meeting of the Federation of Asisan Organizations for Radiation Oncology (FARO) held in conjunction with the 29th Annual Meeting of the Japanese Society for Radiation Oncology (JASTRO)
  • Place of Presentation: Kyoto Japan
  • Year and Date: 2016-11-25
  • Int'l Joint Research
• [Presentation] Particle therapy for inoperable desmoid tumors (2016)
  • Author(s): Yoshiro Matsuo, Yusuke Demizu, Dongcun Jin, Nor Shazrina Sulaiman, Fumiko Nagano, Kazuki Terashima, Osamu Fujii, Sunao Tokumaru, Naoki Hashimoto, Yasue Niwa, Nobukazu Fuwa, Ryohei Sasaki, Tomoaki Okimoto
  • Organizer: The 29th Annual Meeting of the Japanese Society for Radiation Oncology
  • Place of Presentation: Kyoto Japan
  • Year and Date: 2016-11-25
• [Presentation] radiotherapy for cervical lymph node metastases of unknown primary site (2016)
  • Author(s): Yuko Inoue, Kenji Yoshida, Yasuo Ejima, Daisuke Miyawaki, Takeaki Ishihara, Hideki Nishimura, Ryo Nishikawa, Yoshiro Matsuo, Naomi Kiyota, Naoki Otsuki,Kenichi Nibu, Ryohei Sasaki
  • Organizer: The 75th Annual Meeting of the Japan Radiological Society
  • Place of Presentation: Yokohama Japan
  • Year and Date: 2016-04-16
• [Presentation] One-year Experience of MRI Based Image Guided Adaptive Brachytherapy for Cervical Cancer (2016)
  • Author(s): Ryo Nishikawa, Kenji Yoshida, Daisuke Miyawaki, Yoshiro Matsuo, Hiroaki Akasaka, Mayumi Omoteda, Katsusuke Kyotani, Fumie Ota, Satoru Takahashi, Hitoaki Satoh, Yasuhiko Ebina, Hideto Yamada, Ryohei Sasaki
  • Organizer: The 75th Annual Meeting of the Japan Radiological Society
  • Place of Presentation: Yokohama Japan
  • Year and Date: 2016-04-16
• [Presentation] "Definitive Radiotherapy for T3/T4 Hypopharyngeal Squamous Cell Carcinoma (2016)
  • Author(s): Yoshiro Matsuo, Kenji Yoshida, Yuko Inoue, Ryo Nishikawa, Nor Shazrina, Takeaki Ishihara, Daisuke Miyawaki, Yasuo Ejima, Hideki Nishimura, Naomi Kiyota, Miki Saito, Naoki Otsuki, Ken-ichi Nibu, and Ryohei Sasaki.
  • Organizer: The 75th Annual Meeting of the Japan Radiological Society
  • Place of Presentation: Yokohama Japan
  • Year and Date: 2016-04-16