Functional image based image-guided brachytherapy for cervical cancer

• Project/Area Number: 15K19800
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Kyushu University
• Principal Investigator: Atsumi Kazushige 九州大学, 医学研究院, 共同研究員 (70625805)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 子宮頸癌 / 小線源治療 / 放射線腫瘍学 / 小線源 / 機能画像 / PET-MRI / 画像誘導小線源治療 / IGBT / RALS

Outline of Final Research Achievements

A retrospective analysis was done of outcomes of 96 patients with cervical cancer treated with primary radiation therapy with curative intent. 2-year overall and disease-free survival and local control was 87.5%・48.2%・80.2%. Image-guided brachytherapy with a three-dimensional image-based treatment planning for cervical cancer was considered highly effective and safe treatment.

Academic Significance and Societal Importance of the Research Achievements

子宮頚癌に対する3次元的な治療計画による画像誘導小線源治療を行うことにより、効果的な線量投与とリスク臓器への線量軽減を行うことができ、患者の治療効果の向上および副作用の低減につながる可能性が示唆された。