| Budget Amount *help |
¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2015: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
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| Outline of Final Research Achievements |
From November 2013 to March 2016, 42 patients were treated with Gamma Knife (GK) followed bywhole-brain radiotherapy (WBRT) for brain metastasis (BM) with (n = 21) or without (n = 21) meningeal dissemination.The median prescribed dose of GK was 14 Gy at the periphery. The median WBRT dose to isocenter was 30 Gy in 10 fractions. The median number of target BM was 15.
33 did not develop further recurrence until death or last follow-up, while 9 developed recurrence. With a follow-up period up to 24 months, the overall survival rate was 34% at 12 months and median survival time was 8 months. The cumulative incidence of intracranial recurrence was 23% at 12 months. Treatment with low-dose GK followed by WBRT for advanced-stage BM appeared to contribute to local control. Adverse events were mostly acceptable.
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