Development of NTCP model for trismus after radiotherapy of Head & Neck cancer

• Project/Area Number: 15K19808
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Osaka International Cancer Institute (2017); Nara Medical University (2015-2016)
• Principal Investigator: Morimoto Masahiro 地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 医長 (00745359)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2017: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000); Fiscal Year 2016: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000); Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
• Keywords: 開口障害

Outline of Final Research Achievements

Development of NTCP model for trismus after radiotherapy of Head & Neck cancer.
We measured the MIO of Head & Neck cancer patients before and after radiotherapy. Of 132 patients, 32 patients had trismus after radiotherapy.　We contoured the related organ to trismus and detected the important factor for trismus. Baseline MIO and mean dose of contralateral mandible joint is the most important factor for trismus. We could make the useful table for trismus in the clinical practice.

Research Products

• [Journal Article] A phase I/II trial of pemetrexed plus radiotherapy in elderly patients with locally advanced non-small cell lung cancer (2018)
  • Author(s): Tamiya A, Morimoto M, Fukuda S, Naoki Y, Ibe T, Okishio K, Goto H, Yoshii A, Kita T, Nogami N, Fujita Y, Atagi S
  • Journal Title: Investigational New Drugs Volume: 印刷中 Issue: 4 Pages: 667-673
  • DOI: 10.1007/s10637-018-0587-8
  • Peer Reviewed
• [Journal Article] Duration of twice-daily thoracic radiotherapy and time from the start of any treatment to the end of chest irradiation as significant predictors of outcomes in limited-disease small-cell lung cancer (2017)
  • Author(s): Morimoto M, Okishio K, Akira M, Omachi N, Tamiya M, Asami K, Kawaguchi T, Atagi S
  • Journal Title: Clinical Lung Cancer Volume: 18 Issue: 2 Pages: e117-e127
  • DOI: 10.1016/j.cllc.2016.09.004
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 限局型小細胞肺癌に対する同時化学療法併用45 Gy/30分割の加速過分割照射後の再発形式 (2017)
  • Author(s): 森本将裕、三浦幸子、玉本哲郎、本津茂人、木村弘、審良正則、沖塩協一、大町直樹、田宮朗裕、安宅信二、長谷川正俊
  • Organizer: 日本放射線腫瘍学会第30回学術大会
• [Presentation] 71才以上高齢者,切除不能局所進行非小細胞癌に対する,ペメトレキセド+胸部放射線同時併用療法、第I/II相試験 (2017)
  • Author(s): 富澤由雄、田宮朗裕、後藤秀人、野上尚之、吉井明弘、藤田結花、北俊之、井部達也、森本将裕、福田礁一、安宅信二
  • Organizer: 第57回日本呼吸器学会学術講演会
• [Presentation] 3期非小細胞肺癌に対する加速過分割照射の治療成績への影響 (2017)
  • Author(s): 和田健太郎、井川俊樹、金山尚之、平田岳郎、森本将裕、小西浩司、手島昭樹
  • Organizer: 日本放射線腫瘍学会第30回学術大会
• [Presentation] 胃瘻による穿孔性腹膜炎で照射期間が延長した声門上癌の一例 (2016)
  • Author(s): 森本将裕
  • Organizer: 第32回奈良県頭頸部腫瘍研究会
  • Place of Presentation: 橿原
• [Presentation] Sum of the diameters of the primary tumor and metastatic lymph node is an independent prognostic factor in limited-disease small-cell lung cancer treated with accelerated hyperfractionated thoracic radiotherapy at 45 Gy in 30 fractions: a two-institution study (2015)
  • Author(s): Morimoto M, Okishio K, Akira M, Omachi N, Tamiya A, Asami K, Kawaguchi T, Hontsu S, Tamamoto T, Hasegawa M and Atagi S
  • Organizer: The 28th Annual Meeting of JASTRO
  • Place of Presentation: 群馬
  • Year and Date: 2015-11-19
  • Int'l Joint Research
• [Presentation] 二施設の限局型小細胞肺癌に対する放射線治療 (2015)
  • Author(s): 森本将裕、玉本哲郎、長谷川正俊、本津茂人、安宅信二、沖塩協一、大町直樹、田宮朗裕、浅見和弘、川口知哉
  • Organizer: 第311回日本医学放射線学会関西地方会
  • Place of Presentation: 大阪
  • Year and Date: 2015-10-24