| Project/Area Number |
15K19837
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | National Cancer Center Japan |
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Principal Investigator |
Kobayashi Kazuma 国立研究開発法人国立がん研究センター, 中央病院, レジデント (00747610)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 放射線治療 / 非剛体レジストレーション / 有害事象評価 / 時空間的線量合算 / 解剖学的標準化 / 三次元統計解剖学 / 非剛体レジストレーション、 / 線量合算 / 有害事象 / 三次元統計解析法 |
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| Outline of Final Research Achievements |
One of the limitations in the current practice of radiotherapy is that the cumulative, sub-volume doses of organs at risk over the course of fractionated treatment are difficult to be assessed. To quantify the interfactional topographic and dosimetric changes, we adopted a surface-based non-rigid registration by a Gaussian mixture model to document the changing patient anatomy. The proposed method enabled spatiotemporal summation of irradiated radiation doses and predicted the location-by-location difference in the severity of late radiation injury. We will develop the method to establish three-dimensional statistical analysis based on the anatomical standardization for predicting clinical effects in radiation therapy.
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