| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
To clarify the differences in the responses of cells treated with 5-FU to proton beam irradiation according to the position of the cells on the SOBP. OE21 human esophageal squamous cells were irradiated with a 235-MeV proton beam at 4 different positions on the SOBP. The degree of enhancement of the cellular sensitivity to proton beam irradiation by 5-FU was similar across all the positions on the SOBP. Furthermore, a marked increase in the number of residual γH2AX foci at 24 h post irradiation was observed in the cells at the distal end of the SOBP. Our data indicated that the degree of enhancement by 5-FU of the sensitivity of the OE21 cells to proton beam irradiation did not differ significantly depending on the position on the SOBP; however, the 5-FU-induced cytotoxicity tended to be more marked at the distal end than at other positions on the SOBP.
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