Roles of melanoma-associated antigen D2 in gastric cancer

• Project/Area Number: 15K19846
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General surgery
• Research Institution: Nagoya University
• Principal Investigator: HASHIMOTO Ryoji 名古屋大学, 医学部附属病院, 医員 (60747830)
• Research Collaborator: KANDA Mitsuro 名古屋大学, 医学部附属病院, 助教
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: MAGE-D2 / 胃癌 / 血清マーカー

Outline of Final Research Achievements

Sensitive biomarkers are necessary for risk classification of patients with gastric cancer, especially ones at risk of distant metastases. Melanoma-associated antigen (MAGE)-D2 mRNA expression levels were independent of gastric cancer differentiation or subtype. Knockdown of MAGE-D2 resulted in decreased activities of gastric cancer cells. The expression level of MAGE-D2 mRNA was not significantly increased in gastric cancer tissues compared with the corresponding normal adjacent tissues. Increased expression of MAGE-D2 mRNA in gastric cancer tissues was associated with distant metastasis and early recurrence and was an independent prognostic factor. Patients with high preoperative serum MAGE-D2 levels had a more unfavorable prognosis than those with low. MAGE-D2 was associated with metastatic potential of gastric cancer and may represent a promising biomarker, both in gastric tissues and serum samples, for malignant behavior of gastric cancer.

Research Products

• [Journal Article] The Expression of Melanoma-Associated Antigen D2 Both in Surgically Resected and Serum Samples Serves as Clinically Relevant Biomarker of Gastric Cancer Progression (2016)
  • Author(s): Mitsuro Kanda, Shuji Nomoto, Hisaharu Oya, Hideki Takami, Dai Shimizu, Soki Hibino, Ryoji Hashimoto, Daisuke Kobayashi, Chie Tanaka, Suguru Yamada, Tsutomu Fujii, Goro Nakayama, Hiroyuki Sugimoto, Masahiko Koike, Michitaka Fujiwara, Yasuhiro Kodera
  • Journal Title: Annals of Surgical Oncology Volume: 23 Issue: S2 Pages: 214-221
  • DOI: 10.1245/s10434-015-4457-8
  • Peer Reviewed / Open Access
• [Presentation] The expression of melanoma-associated antigen D2 both in surgically resected and serum samples serves as clinically-relevant biomarker of gastric cancer progression (2017)
  • Author(s): Shinichi Umeda, Mitsuro Kanda, Chie Tanaka, Daisuke Kobayashi, Michitaka Fujiwara, Yasuhiro Kodera (研究協力者：Mitsuro Kanda)
  • Organizer: KINGCA (Korea International Gastric Cancer Week) WEEK 2017
  • Place of Presentation: Busan (Korea)
  • Year and Date: 2017-03-23
  • Int'l Joint Research