Analysis of Tumor Immune Evasion of T cell immunoglobulin mucin domain-containing molecule 3 (Tim-3) /Galectin-9 interaction in Breast Cancer
Project/Area Number |
15K19855
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
General surgery
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Research Institution | Yamaguchi University |
Principal Investigator |
MAEDA Noriko 山口大学, 医学部附属病院, 診療助教(4日/週) (10738876)
|
Project Period (FY) |
2015-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | Tim-3 / Galectin-9 / 乳癌 / 腫瘍免疫 |
Outline of Final Research Achievements |
We have demonstrated the expression of Tim-3 and Galectin-9 in tumor cells from patients with breast cancer. No significant associations were identified between Tim-3 / Galectin-9 expression and cliniclo-pathological factors. The disease free survival were significantly shorter in the Tim-3-high group as compared with the Tim-3-low group (p=0.009).The disease free survival were significantly shorter in the Galectin-9-negative group as compared with the Galectin-9-positive group (p=0.008).On univariate analysis, the Tim-3 expression had a significant association with disease -free survival, lymphovascular invasion, HER2, low/absent of Galectin-9 expression and nuclear grade. Multivariate analysis demonstrated the significant role of Tim-3 expression in tumor cells as an independent prognostic factor for patients with breast cancer. The status of Galectin-9 and Tim-3 could be determined on clinical examination and may have treatment value in the future.
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Report
(3 results)
Research Products
(3 results)