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The role of B-cell expression in hepatic ischemia reperfusion injury

Research Project

Project/Area Number 15K19857
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General surgery
Research InstitutionThe University of Tokushima

Principal Investigator

SAITO Yu  徳島大学, 大学院医歯薬学研究部(医学系), 助教 (50548675)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsB細胞 / 肝虚血再灌流障害 / 肝虚血再灌流傷害 / B cell
Outline of Final Research Achievements

Liver ischemia-reperfusion (I/R) injury is one of critical problems to overcome in hepatectomy. Liver B cells among immune cells were focused on for the first time involved in I/R injury. Intrahepatic B cells might increase throughout CXCL13 / CXCR5 axis at relatively early time (2 hours) after reperfusion, and B cells can become therapeutic target in liver I/R injury.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (11 results)

All 2017 2016 2015

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (6 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Mechanism of impairment on liver regeneration in elderly patients: Role of hepatic stellate cell function.2017

    • Author(s)
      Saito Y, Morine Y, Shimada M.
    • Journal Title

      Hepatology Research

      Volume: 印刷中 Issue: 6 Pages: 505-513

    • DOI

      10.1111/hepr.12872

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Loss of Secreted Frizzled-Related Protein-1 expression is associated with poor prognosis in intrahepatic cholangiocarcinoma.2016

    • Author(s)
      Davaadorj M, Saito Y, Morine Y, Ikemoto T, Imura S, Takasu C, Yamada S, Hiroki T, Yoshikawa M, Shimada M.
    • Journal Title

      Eur J Surg Oncol.

      Volume: 43 Issue: 2 Pages: 344-350

    • DOI

      10.1016/j.ejso.2016.11.017

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Nonhematopoietic Erythropoietin Analogue, ARA 290, Inhibits Macrophage Activation and Prevents Damage to Transplanted Islets.2016

    • Author(s)
      Watanabe M, Lundgren T, Saito Y, Cerami A, Brines M, Ostenson CG, Kumagai-Braesch M.
    • Journal Title

      Transplantation.

      Volume: 36 Issue: 3 Pages: 659-664

    • DOI

      10.1097/tp.0000000000001026

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Liver regeneration after splenectomy in patients with liver cirrhosis.2016

    • Author(s)
      Yamada S, Morine Y, Imura S, Ikemoto T, Arakawa Y, Iwahashi S, Saito Y, Yoshikawa M, Teraoku H, Shimada M.
    • Journal Title

      Hepatolgy research

      Volume: 印刷中 Issue: 5 Pages: 443-449

    • DOI

      10.1111/hepr.12573

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dysfunction of liver regeneration in aged liver after partial hepatectomy.2015

    • Author(s)
      Enkhbold C1, Morine Y, Utsunomiya T, Imura S, Ikemoto T, Arakawa Y, Saito Y, Yamada S, Ishikawa D, Shimada M.
    • Journal Title

      Journal of Gastroenterology and Hepatology

      Volume: - Issue: 7 Pages: 1217-1224

    • DOI

      10.1111/jgh.12930

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] PDに対するModified de-rotationを用いた“Complate artery-firstn approach”.2016

    • Author(s)
      齋藤 裕
    • Organizer
      第41回日本外科系連合学会学術集会
    • Place of Presentation
      ナレッジキャピタル(大阪府大阪市)
    • Year and Date
      2016-06-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] HDAC阻害剤は脂肪由来幹細胞からインスリン分泌細胞への分化誘導を促進する2016

    • Author(s)
      齋藤 裕
    • Organizer
      第116回日本外科学会定期学術集会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2016-04-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] The usefulness of peri-operative nutritional assessment in hepatobiliary pancreatic surgery using body composition analyzer and subjective global assessment.2015

    • Author(s)
      齋藤 裕
    • Organizer
      Clinical Congress of American College of Surgeons 2015
    • Place of Presentation
      McCormick Place (Chicago, USA)
    • Year and Date
      2015-10-06
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] The liver regeneration of left lobe after right liver resection;the comparison among caudate lobe,lateral and median segment.2015

    • Author(s)
      齋藤 裕
    • Organizer
      17th Congress of the European Society for Organ Transplantation (ESOT)
    • Place of Presentation
      Square-Brussels Meeting centre(Brussels, Bergium)
    • Year and Date
      2015-09-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 肝胆膵外科手術における周術期栄養評価の有用性に関する研究-体成分分析装置と主観的包括的アセスメント-2015

    • Author(s)
      齋藤裕,安井苑子,吉川雅登,寺奥大貴,山田眞一郎,岩橋衆一,荒川悠佑,池本哲也,森根裕二,居村暁,濱田康弘,島田光生
    • Organizer
      第27回日本肝胆膵外科学会
    • Place of Presentation
      ホテル グランパシフィック LE DAIBA(東京都港区)
    • Year and Date
      2015-06-12
    • Related Report
      2015 Research-status Report
  • [Presentation] 大量肝切除モデルラットにおける茶Catechinの効果2015

    • Author(s)
      齋藤裕
    • Organizer
      第30回日本shock学会総会
    • Place of Presentation
      京王プラザホテル八王子(東京都八王子市)
    • Year and Date
      2015-05-22
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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