Analysis of exosomal miRNA in the patients with tripe negative breast cancer; role of miRNAs as predictive factors for treatment

Research Project

Project/Area Number	15K19861
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	General surgery
Research Institution	Kumamoto University
Principal Investigator	Sueta Aiko 熊本大学, 大学院生命科学研究部(医), 助教 (70749720)
Project Period (FY)	2015-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2015: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords	エクソソーム / miRNA / 体液診断
Outline of Final Research Achievements	We evaluated the expression of exosomal miRNA which were derived from serum in the patients with hormonal receptor-positive and HER2-negative breast cancer. The patients with pCR had higher levels of miR-1273e, miR-4448, miR-2392, miR-2467-3p and miR-4800-3p and lowere levels of miR-637、miR-874-3p、miR-423-5p、miR-1203、miR-3918、miR-4419a、miR-3177-5p、miR-4707-3p、miR-4740-3p、miR-210-5p and 6796-3p compared to those with non-pCR.

Report

(3 results)