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The effect of hypoxia on the resistence of drug therapy for breast cancer

Research Project

Project/Area Number 15K19862
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General surgery
Research InstitutionOsaka City University

Principal Investigator

NODA Satoru  大阪市立大学, 大学院医学研究科, 講師 (20382103)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords乳癌 / 低酸素 / 造影超音波検査 / 薬物療法
Outline of Final Research Achievements

The heterogeneity of blood flow and the hypoxia in tumor have been reported to be associated with malignant potential and metastatic potential of malignat neoplasms. Contrast enhancement ultrasonography is able to assess the blood flow in tumor. It might be easily able to evaluate the malignant potential of tumor. We found that the blood flow in tumor bacame homogenous when drug therapy had good response for tumor.
We analyzed the association between pathological background of breast cancer and blood flow in tumor using contrast enhanced ultrasonography. It had been found that breast cancer witout estrogen receptor more frequently had the heterogeneity of blood flow in tumor. The expression of estrogen receptor is target for endocrine therapy. It was suggested that endocrine therapy might not be usuful for breast tumor with heterogeneity of blood flow.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (10 results)

All 2017 2016

All Presentation (10 results) (of which Int'l Joint Research: 2 results)

  • [Presentation] Grade別にみた非浸潤性乳管癌のソナゾイド造影超音波検査所見の比較2017

    • Author(s)
      福田 雅代
    • Organizer
      第25回日本乳癌学会学術集会
    • Place of Presentation
      マリンメッセ福岡(福岡)
    • Year and Date
      2017-07-13
    • Related Report
      2016 Research-status Report
  • [Presentation] 粘液癌におけるソナゾイド造影超音波検査所見の特徴2017

    • Author(s)
      中村 桂子
    • Organizer
      第25回日本乳癌学会学術集会
    • Place of Presentation
      マリンメッセ福岡(福岡)
    • Year and Date
      2017-07-13
    • Related Report
      2016 Research-status Report
  • [Presentation] Characteristic of findings of contrast-enhanced ultrasonography with Sonazoid for mucinous breast cancer2017

    • Author(s)
      Keiko Nakamura
    • Organizer
      24th Asia Pacific Cancer Conference
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2017-06-22
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 乳腺造影超音波による腫瘍内血流の評価と悪性度との関連2017

    • Author(s)
      野田 諭
    • Organizer
      第117回日本外科学会定期学術集会
    • Place of Presentation
      横浜市(パシフィコ横浜)
    • Year and Date
      2017-04-27
    • Related Report
      2016 Research-status Report
  • [Presentation] 乳腺造影超音波検査による腫瘍内血流の評価と悪性度の関連2017

    • Author(s)
      野田 諭
    • Organizer
      第117回日本外科学会定期学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Characteristics of findings of contrast-enhanced ultrasonography with Sonazoid for mucinous breast cancer2017

    • Author(s)
      Keiko Nakamura
    • Organizer
      24th Asia Pacific Cancer Conference
    • Related Report
      2017 Annual Research Report
  • [Presentation] Grade別に見た非浸潤性乳管癌のソナゾイド造影超音波検査所見の比較2017

    • Author(s)
      福田 雅代
    • Organizer
      第25回日本乳癌学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 粘液癌におけるソナゾイド造影超音波検査所見の特徴2017

    • Author(s)
      中村 佳子
    • Organizer
      第25回日本乳癌学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 乳癌術前化学療法奏効例におけるソナゾイド造影超音波検査の有用性2016

    • Author(s)
      中村佳子
    • Organizer
      第24回日本乳癌学会学術総会
    • Place of Presentation
      東京ビッグサイト(東京都江東区)
    • Year and Date
      2016-06-17
    • Related Report
      2015 Research-status Report
  • [Presentation] USEFULNESS OF CONTRAST-ENHANCED ULTRASOUND WITH SONAZOID FOR EVALUATION OF RESIDUAL TUMOR AFTER NEOADJUVANT CHEMOTHERAPY FOR BREAST CANCER PATIENTS.2016

    • Author(s)
      Keiko Nakamura
    • Organizer
      Global Breast Cancer Conference 2016
    • Place of Presentation
      済州市(韓国)
    • Year and Date
      2016-04-28
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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