Assessment of the relationship between pouchitis and internal antimicrobial protein after surgery in ulcerative colitis

Research Project

Project/Area Number	15K19868
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Digestive surgery
Research Institution	Tohoku University
Principal Investigator	WATANABE KAZUHIRO 東北大学, 大学病院, 助教 (30569588)
Research Collaborator	KOUNO EMIKO
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	潰瘍性大腸炎 / 家族性大腸腺腫症 / 回腸嚢炎 / 抗菌タンパク / 抗菌ペプチド / RELMβ/FIZZ2 / RELMβ
Outline of Final Research Achievements	Total colectomy with ileal pouch-anal anastomosis (IPAA) is a standard surgical procedure for ulcerative colitis (UC) and familial adenomatous polyposis (FAP). Pouchitis is a major complication after IPAA in patient with UC, which pathogenesis is unknown. RELMβ/FIZZ2 (resistin-like molecule beta／Found in inflammatory zone-2) is a colonic epithelial protein which expression decreases in patients with UC in our past study. This study aims to evaluate (1) the antimicrobial activity of RELMβ/FIZZ2, (2) the factors which modulate RELMβ/FIZZ2 expression, and (3) the expression of RNA and/or antimicrobial protein in ileal pouch and stool after IPAA.