Analysis of LPCAT3 in intestinal mucosa of Crohn's disease

Research Project

Project/Area Number	15K19877
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Digestive surgery
Research Institution	Hamamatsu University School of Medicine
Principal Investigator	Harada Takashi 浜松医科大学, 医学部附属病院, 診療助教 (00537251)
Project Period (FY)	2015-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	炎症性腸疾患 / クローン病 / 腸管内分泌細胞
Outline of Final Research Achievements	Distribution of phosphatidylcholine in endoscopic normal ileal mucosa and normal iliac mucosa of Crohn's disease was compared using IMS. METHODS: The endoscopic normal ileal mucosa of the resected intestinal tract of Crohn 's disease patients was compared with the ileal mucosa of cancer patient noncancerous area by IMS. RESULTS: IMS found that Arachidonic PC was more in Crohn's disease mucosa. Furthermore, it was found that the enzyme LPCAT3 involved in the synthesis of Arachidonic PC was expressed more frequently in the mucosa of Crohn's disease intestinal tract. Crohn's disease ileal endocrine cells express LPCAT3 in a large amount, so it is thought that it secretes a large amount of 5-HT to the stimulus and is one cause of abdominal pain and diarrhea.