Characterization of the T cell repertoire by deep T cell receptor sequencing in tissues and blood from patients with advanced colorectal cancer treated with cetuximab.
Project/Area Number |
15K19894
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Digestive surgery
|
Research Institution | Yamaguchi University |
Principal Investigator |
INOUE Yuka 山口大学, 医学部附属病院, 診療助教(4日/週) (50749835)
|
Project Period (FY) |
2015-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 癌免疫学 / 進行大腸癌 / セツキシマブ / TCRレパートリー / TCR-α / TCR-β / 多様性 / 切除不能進行大腸癌 / TCR / TCR解析 |
Outline of Final Research Achievements |
We started this study, after approval of IRB (Institutional Review Board). Three cases were enrolled this study by now. During this study period, we published a paper of the study which was the opportunity to start this study. Furthermore, we published a paper and reported about analyzing the T cell repertoire in blood samples and cancer tissues in advanced colorectal cancer patients that had received cancer peptide vaccine and oxaliplatin-based chemotherapy, and investigating the relationship between the TCR diversity and the PFS (progression free survival).
|
Report
(3 results)
Research Products
(3 results)
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[Journal Article] Cetuximab strongly enhances immune cell infiltration into liver metastatic sites in colorectal cancer.2017
Author(s)
Inoue Y, Hazama S, Suzuki N, Tokumitsu Y, Kanekiyo S, Tomochika S,Tsunedomi R, Tokuhisa Y, Iida M, Sakamoto K, Takeda S, Ueno T, Yoshino S and Nagano H.
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Journal Title
Cancer Sci.
Volume: 108(3)
Issue: 3
Pages: 455-460
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Characterization of T cell repertoire in tumor tissues and blood in advanced colorectal cancers through deep T cell receptor sequencing2016
Author(s)
Tamura K, Hazama S, Yamaguchi R, Imoto S, Takenouchi H, Inoue Y, Kanekiyo S, Shindo Y, Satoru Miyano S, Nakamura Y, Kiyotani K
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Journal Title
Oncology Letters
Volume: 印刷中
Issue: 6
Pages: 3643-3649
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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