Research Project
Grant-in-Aid for Young Scientists (B)
Molecular mechanisms driving peritoneal dissemination still remain poorly understood. Here, we aimed to provide novel insights into the molecular mechanisms that drive the peritoneal dissemination of GC. We performed combined expression analysis with in vivo-selected metastatic cell lines and samples from 200 GC patients to identify driver genes of peritoneal dissemination. We identified a peritoneal dissemination-associated expression signature, whose profile correlated with those of genes related to development, focal adhesion, and the extracellular matrix. Among the genes comprising the expression signature, we identified that genes (DDR2 and PLOD2) as a potential regulator of peritoneal dissemination. These three gene were identified as a driver gene for GC dissemination from the combined expression signature and can potentially serve as a novel therapeutic target for inhibiting GC peritoneal dissemination.
All 2016 2015
All Journal Article (3 results) (of which Int'l Joint Research: 3 results, Peer Reviewed: 3 results, Open Access: 3 results) Presentation (3 results) (of which Int'l Joint Research: 1 results)
Sci Rep.
Volume: 6 Issue: 1 Pages: 22371-22371
10.1038/srep22371
120006352400
PLoS Genetics
Volume: 12 Issue: 2 Pages: 1-24
10.1371/journal.pgen.1005778
Volume: 6 Issue: 1 Pages: 27525-27525
10.1038/srep27525
