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Therapeutic implication for cancer-associated fibroblasts (CAF) in cholangiocarcinoma

Research Project

Project/Area Number 15K19900
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Digestive surgery
Research InstitutionKumamoto University

Principal Investigator

IMAI Katsunori  熊本大学, 医学部附属病院, 助教 (60555746)

Research Collaborator OKABE Hirohisa  熊本大学, 医学部附属病院, 非常勤診療医師 (40573621)
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords癌関連線維芽細胞(CAF) / 胃癌 / CXCL12 / CXCR4 / 胃接合部癌 / 線維芽細胞 / CAF
Outline of Final Research Achievements

Cancer associated fibroblasts (CAFs) were hardly isolated from human cholangiocarcinoma tissue samples because tissue was stiff and elastic. Instead, CAFs were isolated from human gastric cancer tissues. Activation of CAFs was confirmed by expression of SMA by immunocytochemistry. Three out of six human CAFs overexpressed CXCL12. Co-culture of CXCL12-expressing human CAF and gastric cancer cell line, OACM5.1C expressing CXCR4 induced invasive capacity of cancer cell. On the other hand, this interaction was prohibited by CXCR4 antagonist.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (4 results)

All 2016 2015

All Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results)

  • [Journal Article] C5a receptor (CD88) promotes motility and invasiveness of gastric cancer by activating RhoA.2016

    • Author(s)
      Kaida T, Nitta H, Kitano Y, Yamamura K, Arima K, Izumi D, Higashi T, Kurashige J, Imai K, Hayashi H, Iwatsuki M, Ishimoto T, Hashimoto D, Yamashita Y, Chikamoto A, Imanura T, Ishiko T, Beppu T, Baba H.
    • Journal Title

      Oncotarget.

      Volume: 20(7) Issue: 51 Pages: 84798-84809

    • DOI

      10.18632/oncotarget.12656

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early Recurrence After Hepatectomy for Colorectal Liver Metastases: What Optimal Definition and What Predictive Factors?2016

    • Author(s)
      Imai K, Allard MA, Benitez CC, Vibert E, Sa Cunha A, Cherqui D, Castaing D, Bismuth H, Baba H, Adam R.
    • Journal Title

      Oncologist

      Volume: 21(7) Issue: 7 Pages: 887-94

    • DOI

      10.1634/theoncologist.2015-0468

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nomogram for prediction of prognosis in patients with initially unresectable colorectal liver metastases.2016

    • Author(s)
      Imai K, Allard MA, Castro Benitez C, Vibert E, Sa Cunha A, Cherqui D, Castaing D, Bismuth H, Baba H, Adam R.
    • Journal Title

      Br J Surg

      Volume: 103(5) Issue: 5 Pages: 590-9

    • DOI

      10.1002/bjs.10073

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Failure to Achieve a 2-Stage Hepatectomy for Colorectal Liver Metastases: How to Prevent It?2015

    • Author(s)
      Imai K, Benitez CC, Allard MA, Vibert E, Cunha AS, Cherqui D, Castaing D, Bismuth H, Baba H, Adam R.
    • Journal Title

      Ann Surg.

      Volume: 262(5) Issue: 5 Pages: 772-8

    • DOI

      10.1097/sla.0000000000001449

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research

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Published: 2015-04-16   Modified: 2018-03-22  

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