| Project/Area Number |
15K19916
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Digestive surgery
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|---|
| Research Institution | Kagawa University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 食道癌 / 根治的化学放射線療法 / 治療抵抗性 / 効果予測マーカー |
|---|
| Outline of Final Research Achievements |
To predict response to CRT for ESCC, I focused on DNA repair pathway. I selected 46 candidate DNA repair genes for mutation analysis. Then, I analyzed 51 biopsy samples for the 46 DNA repair genes by target deep sequencing, and PARP1 SNP associated with response to CRT. To confirm the result, I analyzed another 61 biopsy samples, and I can not confirm the result. PARP1 SNP may not be predict resistance to CRT for ESCC.
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