Challenge for pulmonary reproduction after lung resection by the paracrine effect of growth factors secreted from mesenchymal stem cell sheets
| Project/Area Number |
15K19940
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory surgery
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 代償性肺成長 / 間葉系幹細胞 / 低酸素プレコンディショニング / 間葉系幹細胞シート / 低酸素プレコンディショニング法 / 術後肺再生 / パラクライン効果 |
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| Outline of Final Research Achievements |
We focused on mesenchymal stem cells seem to secrete growth factors related to compensatory growth of the remaining lung after pneumonectomy and analyzed the characteristics of them. Consequently, it was shown that rabbit bone marrow-derived mesenchymal stem cells possessed the capacity to differentiate into osteoblasts, chondrocytes, adipocytes lineages. Hypoxic preconditioning (2% 02) increased secretion of vascular endothelial growth factor (VEGF) in mesenchymal stem cell sheets. Furthermore, the conditioned medium augmented tube formation of human vascular endothelial cells and decreased cardiac fibroblast migration.
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Report
(3 results)
Research Products
(3 results)
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[Journal Article] Autologous preconditioned mesenchymal stem cell sheets improve left ventricular function in a rabbit old myocardial infarction model.2016
Author(s)
Tanaka Y, Shirasawa B, Takeuchi Y, Kawamura D, Nakamura T, Samura M, Nishimoto A, Ueno K, Morikage N, Hosoyama T, Hamano K.
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Journal Title
Am J Transl Res.
Volume: 8
Pages: 2222-2233
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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