| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
We focused on mesenchymal stem cells seem to secrete growth factors related to compensatory growth of the remaining lung after pneumonectomy and analyzed the characteristics of them. Consequently, it was shown that rabbit bone marrow-derived mesenchymal stem cells possessed the capacity to differentiate into osteoblasts, chondrocytes, adipocytes lineages. Hypoxic preconditioning (2% 02) increased secretion of vascular endothelial growth factor (VEGF) in mesenchymal stem cell sheets. Furthermore, the conditioned medium augmented tube formation of human vascular endothelial cells and decreased cardiac fibroblast migration.
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