Effect of inhibiting pleural adhesion with aspirin in rats
| Project/Area Number |
15K19943
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
Ishihara Shunta 京都府立医科大学, 医学(系)研究科(研究院), 助教 (60751279)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Keywords | 胸膜癒着 / 癒着抑制 / アスピリン |
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| Outline of Final Research Achievements |
In this study, we investigated the effect of aspirin on the pleural adhesion in rats. We used a total of 16 Spague-Dawley male rats aged 10 weeks. We performed procedure of causing adhesion and allocated control group or aspirin group t random. After 14 days, we performed re-thoracotomy and measured the adhesion length. The adhesion length of aspirin group was significantly shorter than that of control group (8.7 ± 2.0 mm vs 11.2 ± 1.1 mm, p= 0.024). And the adhesion section was analyzed by immunochemicalhistory staining with PDGF, VEGF, α-SMA, PDGFR-α on day 1, 2, 3, 7 and day 14 after same procedure. The expression of PDGF on day1 and that of α-SMA on day3 in aspirin group was more weaken than in control group. The expression of PDGFR-α on macrophage was not shown entirely in aspirin group on day3. Aspirin inhibits postoperative pleural adhesion.
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Report
(3 results)
Research Products
(1 results)
