Elucidation of immunological mechanism in malignant brain tumor of HUVEC vaccine and expansion of adaptation to hemangioblastoma
| Project/Area Number |
15K19950
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | HUVECワクチン / 血管芽腫 / 腫瘍血管新生 / 中枢神経系血管芽腫 |
|---|
| Outline of Final Research Achievements |
Human umbilical vein endothelial cell (HUVEC) vaccine is thought to inhibit tumor growth by inhibiting tumor angiogenesis, and we have been conducting the clinical trial of HUVEC vaccine at the Tokyo University Hospital. It was confirmed that HUVEC specific immunity was induced by the vaccine treatment and it was shown that there is a possibility of improving prognosis in the patients with malignant brain tumors. It also showed the possibility of culturing HUVEC in human platelet preparations. Furthermore, comprehensive genome analysis was performed on hemangioblastomas the tumor angiogenesis of which are remarkable. Our study showed the importance of VHL gene abnormality in tumorgenesis of hemangioblastomas. These results will able to lead to the future elucidation of the mechanism of neovascularization and introduction of HUVEC vaccine therapy to hemangioblastomas
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Development of Database and Genomic Medicine for von Hippel-Lindau Disease in Japan2017
Author(s)
Takayanagi S, Mukasa A, Nakatomi H, Kanno H, Kuratsu JI, Nishikawa R, Mishima K, Natsume A, Wakabayashi T, Houkin K, Terasaka S, Yao M, Shinohara N, Shuin T, Saito N.
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Journal Title
Neurologia medico-chirurgica
Volume: 57
Issue: 2
Pages: 59-65
DOI
NAID
ISSN
0470-8105, 1349-8029
Related Report
Peer Reviewed / Open Access
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[Journal Article] Differences in genetic and epigenetic alterations between von Hippel-Lindau disease-related and sporadic hemangioblastomas of the central nervous system.2017
Author(s)
Takayanagi S, Mukasa A, Tanaka S, Nomura M, Omata M, Yanagisawa S, Yamamoto S, Ichimura K, Nakatomi H, Ueki K, Aburatani H, Saito N
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Journal Title
Neuro Oncol.
Volume: 印刷中
Issue: 9
Pages: 1-7
DOI
Related Report
Peer Reviewed / Open Access
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