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Complete regulation of glioma stem cell by notch and Akt signal inhibition

Research Project

Project/Area Number 15K19956
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurosurgery
Research InstitutionKanazawa University

Principal Investigator

tanaka shingo  金沢大学, 医学系, 協力研究員 (40507084)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
KeywordsNotch阻害薬 / Akt阻害薬 / 膠芽腫 / Notch阻害剤 / Akt阻害剤 / 膠芽腫幹細胞
Outline of Final Research Achievements

Glioblastoma is the most malignant primary brain tumor in humans. The patinets with glioblastoma have a uniformly poor prognosis. The significance of targeting glioblastoma-stem cells may be important for successful treatment. In this study, we analyzed the efficacy of the Nothc inhibitor and Akt inhibitor for glioblastoma stem cell with Notch inhibitor resistance. Notch inhibitor concomitant Akt inhibitor treatment enhanced the effect by monothearapy such as suppression of cell proliferation and stemness maintenance, and promotion of apoptosis.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (4 results)

All 2016 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 1 results,  Open Access: 1 results) Presentation (2 results)

  • [Journal Article] Chronic spatial working memory deficit associated with the superior longitudinal fasciculus: a study using voxel-based lesion-symptom mapping and intraoperative direct stimulation in right prefrontal glioma surgery2016

    • Author(s)
      Kinoshita K, Hayashi Y, et al.
    • Journal Title

      J Neurosurg

      Volume: 19 Issue: 4 Pages: 1-19

    • DOI

      10.3171/2015.10.jns1591

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Strong therapeutic potential of γ-secretase inhibitor MRK003 for CD44-high and CD133-low glioblastoma initiating cells2015

    • Author(s)
      Tanaka S, Nakada M, Yamada D, Nakano I, Todo T, Ino Y, Hoshii T, Tadokoro Y, Ohta K, Ali MA, Hayashi Y, Hamada J, Hirao A.
    • Journal Title

      J Neurooncol.

      Volume: 121 Issue: 2 Pages: 239

    • DOI

      10.1007/s11060-014-1630-z

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Notch阻害剤抵抗性膠芽腫幹細胞に対するAkt阻害剤併用の有効性2015

    • Author(s)
      田中慎吾、中野伊知郎、平尾敦、中田光俊
    • Organizer
      第33回日本脳腫瘍学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2015-12-06
    • Related Report
      2015 Research-status Report
  • [Presentation] 膠芽腫幹細胞に対するγ-セクレターゼ阻害剤MRK003の効果と感受性マーカーの解析2015

    • Author(s)
      田中慎吾、平尾敦、中野伊知郎、藤堂具紀、稲生靖、中田光俊
    • Organizer
      第74回日本脳神経外科学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2015-10-14
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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