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Nrf2 activator attenuates brain ischemia-reperfusion injury.

Research Project

Project/Area Number 15K19960
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurosurgery
Research InstitutionHyogo Medical University (2016)
Gifu University (2015)

Principal Investigator

Takagi Toshinori  兵庫医科大学, 医学部, 助教 (00452152)

Research Collaborator Hara Hideaki  岐阜薬科大学, 薬効解析学, 教授
Yoshimura Shinichi  兵庫医科大学, 医学部, 主任教授
Iwama Toru  岐阜大学, 大学院医学系研究科 脳神経外科, 教授
Yamauchi Keita  岐阜大学, 大学院医学系研究科 脳神経外科
Egashira Yusuke  岐阜大学, 大学院医学系研究科 脳神経外科
Imai Takahiko  岐阜薬科大学, 薬効解析学
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsNrf2 / 脳虚血再灌流障害 / 脳血液関門 / 酸化ストレス
Outline of Final Research Achievements

Bardoxylone methyl(BARD)and novel Nrf2 activator, RS-9 decreased cerebral infarction and improve neurological findings due to ischemia-reperfusion injury. In addition, BARD decreased hemorrhagic infarction and improve neurological findings under warfarin administration. BARD also attenuates hyper-permeability of blood brain barrier and ameliorates the injury of vascular endothelial cells and pericytes.
These results demonstrated the neuroprotective effects of Nrf2 activator and protection of blood brain barrier.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (4 results)

All 2017 2016 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Remarks (1 results)

  • [Journal Article] Cilostazol ameliorates collagenase-induced cerebral hemorrhage by protecting the blood brain barrier2017

    • Author(s)
      Takagi T, Imai T, Mishiro K, Ishisaka M, Tsujimoto M, Ito H, Nagashima K, Matsukawa H, Tsuruma K, Shimazawa M, Yoshimura S, Kozawa O, Iwama T, Hara H.
    • Journal Title

      J Cereb Blood Flow Metab.

      Volume: 37 Issue: 1 Pages: 123-139

    • DOI

      10.1177/0271678x15621499

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nrf2 activator ameliorates hemorrhagic transformation in focal cerebral ischemia under warfarin anticoagulation2016

    • Author(s)
      Imai, T., Takagi, T., Kitashoji, A., Yamauchi, K., Shimazawa, M., Hara, H.
    • Journal Title

      Neurobiology of Disease

      Volume: 89 Pages: 136-146

    • DOI

      10.1016/j.nbd.2016.02.001

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel nuclear factor erythroid 2-related factor 2 (Nrf2) activator RS9 attenuates brain injury after ischemia reperfusion in mice.2016

    • Author(s)
      Yamauchi K, Nakano Y,Imai T, Takagi T, Tsuruma K, Shimazawa M, Iwama T, Hara H.
    • Journal Title

      Neuroscience

      Volume: 333 Pages: 302-10

    • DOI

      10.1016/j.neuroscience.2016.07.035

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Remarks] 岐阜大学医学部脳神経外科

    • URL

      http://www.med.gifu-u.ac.jp/neurosurgery/

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2018-03-22  

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