Mutational landscape and clonal architecture in secondary glioblastomas

• Project/Area Number: 15K19964
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: Kyoto University
• Principal Investigator: Suzuki Hiromichi 京都大学, 医学研究科, 特定助教 (90751024)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: グリオーマ / クローン進化 / 腫瘍内多様性 / IDH

Outline of Final Research Achievements

Lower grade glioma (WHO grade II and III glioma) is slowly progressive but incurable disease. Recently, our group revealed that lower grade glioma is divided into three subgroups based on genetic alterations. In this study, we identified subgroup-specific genetic alterations that affected the tumor progression in lower grade glioma. The subset of patients with identified genetic alterations had poor survival, which will lead us to the better management of LGG patients.

Research Products

• [Journal Article] Mutational landscape and clonal architecture in grade II and III gliomas (2015)
  • Author(s): Suzuki H, Aoki K, Natsume A, Ogawa S. et al.
  • Journal Title: Nat Genet. Volume: 47 Issue: 5 Pages: 458-468
  • DOI: 10.1038/ng.3273
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 低悪性度神経膠腫における遺伝子異常とクローン進化の解明 (2015)
  • Author(s): 鈴木啓道, 青木恒介, 千葉健一, 佐藤悠佑、塩澤裕介、白石友一、島村徹平、新井田厚司、宮野悟、夏目敦至、小川誠司
  • Organizer: 第38回分子生物学会年会・第88回生化学会大会合同大会BMB2015
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-02
  • Invited
• [Presentation] 低悪性度神経膠腫における遺伝子変異の全体図とクローン進化の解明 (2015)
  • Author(s): 鈴木啓道, 青木恒介, 千葉健一, 白石友一, 本村和也, 大岡史治, 中村英夫, 溝口昌弘, 阿部竜也, 村垣善浩, 伊藤以知郎, 渡邊麗子, 眞田昌, 若林俊彦, 小川誠司, 夏目敦至
  • Organizer: 第74回 日本脳神経外科学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2015-10-14
• [Presentation] The landscape and clonal architecture in lower grade glioma (2015)
  • Author(s): Hiromichi Suzuki, Kosuke Aoki, Kenichi Chiba, Yusuke Sato, Yusuke Shiozawa, Yuichi Shiraishi, Teppei Shimamura, Atsushi Niida, Kazuya Motomura, Fumiharu Ohka, Hideo Nakamura, Masahiro Mizoguchi, Tatsuya Abe, Yoshihiro Muragaki, Reiko Watanabe, Ichiro Ito, Toshihiko Wakabayashi, Seishi Ogawa and Atsushi Natsume
  • Organizer: 2015ASCO Annual Meeting
  • Place of Presentation: シカゴ
  • Year and Date: 2015-06-02
  • Int'l Joint Research
• [Presentation] The landscape and clonal architecture in lower grade glioma (2015)
  • Author(s): Hiromichi Suzuki, Kosuke Aoki, Kenichi Chiba, Yusuke Sato, Yusuke Shiozawa, Yuichi Shiraishi, Atsushi Niida, Teppei Shimamura, Masashi Sanada, Satoru Miyano, Toshihiko Wakabayashi, Atsushi Natsume, Seishi Ogawa
  • Organizer: AACR Annual Meeting 2015
  • Place of Presentation: フィラデルフィア
  • Year and Date: 2015-04-21
  • Int'l Joint Research
• [Remarks] 京都大学医学部医学研究科 腫瘍生物学講座
  • URL: http://plaza.umin.ac.jp/kyoto_tumorpatho/