| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
The physiological functions of reelin in vivo during adulthood remain controversial. We tested if there is a behavioral phenotype in the adult heterozygous reeler mice on the skilled reach task. The heterozygous reeler mice could learn to reach and grasp singly presented pellets, but the successfully retrieved number of pellets was lower than that achieved by the WT. We then assessed the physiological integrity of the motor cortex in HRM and WT littermates, before and after the training on skilled reach, using intracortical microstimulation. We found that this forelimb training exerted bilateral effects on the cortical forelimb map constitution. The level of synaptophysin and neurofilament expression levels heighten in the WT post-training. We are currently summarizing the results for post-stroke learning outcome measures.
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