MicroRNA regulating metabolic stress enhances therapeutic sensitivity in glioma
| Project/Area Number |
15K19973
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
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| Research Institution | Kagawa University |
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Principal Investigator |
Ogawa Daisuke 香川大学, 医学部附属病院, 病院助教 (70524057)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | microRNA / miR-451 / 脳腫瘍 / グリオーマ / AMPK / Oct1 / microRNA-451 / 薬剤感受性 / テモゾロマイド |
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| Outline of Final Research Achievements |
The aim of this study was to see if miR-451, a one of microRNAs which regulates metabolic stress, will increase therapeutic sensitivity of brain tumor cells. Upregulation of miR-451 in brain tumor cells increased chemo-sensitvity and radiation sensitivity causing brain tumor cells to death. We found Oct1 as a positive transcription factor to increase expression level of miR-451. We also found that miR-451 expression level was increased in high blood glucose model rats.
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Report
(4 results)
Research Products
(13 results)
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[Presentation] Glioma cells adapt metabolic stress by regulating mir-451 expression2016
Author(s)
Daisuke Ogawa, Atsushi Matsumoto, Masaaki Kochi, Masaki Okada, Keisuke Miyake, Takashi Tamiya, EA Chiocca and Jakub Godlewski
Organizer
the 13th Asian Society for Neuro-Oncology (ASNO) Meeting / the 9th COGNO (Cooperative Trials Group for Neuro-Oncology) Annual Scientific Meeting
Place of Presentation
シドニー、オーストラリア
Year and Date
2016-09-11
Related Report
Int'l Joint Research
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