| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
The aim of this study was to see if miR-451, a one of microRNAs which regulates metabolic stress, will increase therapeutic sensitivity of brain tumor cells. Upregulation of miR-451 in brain tumor cells increased chemo-sensitvity and radiation sensitivity causing brain tumor cells to death. We found Oct1 as a positive transcription factor to increase expression level of miR-451. We also found that miR-451 expression level was increased in high blood glucose model rats.
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