The analysis of expression of treatment-related genes and glioma stem cells in the hypoxic region of glioblastoma.
| Project/Area Number |
15K19977
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
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| Research Institution | Yokohama City University |
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Principal Investigator |
OHTAKE Makoto 横浜市立大学, 附属病院, 指導診療医 (70644607)
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| Research Collaborator |
KAWAHARA Nobutaka
MURATA Hidetoshi
UMEMURA Masanari
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 神経膠芽腫 / 低酸素領域 / CuATSM / 幹細胞 / MGMT遺伝子 |
|---|
| Outline of Final Research Achievements |
Glioblastoma is the most common and most aggresive tumor in adults. One of the factors of treatment resistence is the existence of hypoxic regions located in the tumor. Cu-ATSM (Cu-diacetyl-bis(N4-methylthiosemicarbazone)) was developed as a hypoxic tracer in PET. Our previous reports revealed a relationship between Cu-ATSM uptake and hypoxic marker expression. If the treatment resistent factors are mainly existed in the hypoxic regions of glioblastoma, the safe treatment targeted the hypoxic regions such as stereotactic strategy becomes possible. In this study, we took the hypoxix tissue at the surgery, and performed immunopathological examinations and gene analysis. Moreover, we examined the target therapy for Cu-ATSM high uptake regions. Now we follow up the clinical course and examine the relationship of tissue status and clinical outcome.
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Report
(3 results)
Research Products
(2 results)
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[Journal Article] Hyperthermia and chemotherapy using Fe(Salen) nanoparticles might impact glioblastoma treatment.2017
Author(s)
Ohtake M, Umemura M, Sato I, Akimoto T, Oda K, Nagasako A, Kim JH, Fujita T, Yokoyama U, Nakayama T, Hoshino Y, Ishiba M, Tokura S, Hara M, Muramoto T, Yamada S, Masuda T, Aoki I, Takemura Y, Murata H, Eguchi H, Kawahara N, Ishikawa Y.
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Journal Title
Sci Rep.
Volume: 7
Issue: 1
Pages: 42783-42783
DOI
Related Report
Peer Reviewed / Open Access
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