central nervous malignant lymphoma with IL-10 secretion

• Project/Area Number: 15K19981
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: Kanazawa University
• Principal Investigator: Sasagawa Yasuo 金沢大学, 附属病院, 特任助教 (70387372)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: IL-10 / Lymphoma / cerebrospinal fliud / 中枢神経系リンパ腫 / インターロイキン10 / 脳脊髄液

Outline of Final Research Achievements

Preoperative diagnosis of central nervous system (CNS) lymphoma is very important in neurosurgery because biopsy can be selected for pathological diagnosis.The purpose of this study was to evaluate the diagnostic value of IL-10 in cerebrospinal fluid (CSF) in patients with CNS lymphoma compared with other CNS diseases, including CNS tumors and inflammatory diseases. CSF IL-10 were measured in patients with CNS lymphoma and 26 non-lymphoma patients. CSF IL-10 was detected at significant levels. These results indicate that CSF IL-10 is a superior biomarker for initial screening for patients with CNS lymphoma and give useful information for planning of a neurosurgical procedure.

Research Products

• [Journal Article] Carotid artery protrusion and dehiscence in patients with acromegaly. (2016)
  • Author(s): Sasagawa Y, Tachibana O, Doai M, Hayashi Y, Tonami H, Iizuka H, Nakada M.
  • Journal Title: Pituitary Volume: 19 Issue: 5 Pages: 482-7
  • DOI: 10.1007/s11102-016-0728-z
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Midline dural filum of the sellar floor: Its relationship to the septum attachment to the sellar floor and the ossification in the sphenoid sinus. (2016)
  • Author(s): Hayashi Y, Kita D, Iwato M, Fukui I, Sasagawa Y, Oishi M, Tachibana O, Nakada M.
  • Journal Title: Clin Neurol Neurosurg Volume: 147 Pages: 53-8
  • DOI: 10.1016/j.clineuro.2016.05.007
  • NAID: 120005830644
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Rapid enlargement of an intracranial germ cell tumor after gonadotropin hormone therapy. (2016)
  • Author(s): Sasagawa Y, Tachibana O, Nakagawa A, Nakada S, Nojima T, Koya D, Iizuka H.
  • Journal Title: J Clin Neurosci Volume: 31 Pages: 185-8
  • DOI: 10.1016/j.jocn.2016.01.033
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Pediatric symptomatic Rathke cleft cyst compared with cystic craniopharyngioma. (2016)
  • Author(s): Hayashi Y, Kita D, Fukui I, Sasagawa Y, Oishi M, Okajima M, Tachibana O, Nakada M.
  • Journal Title: Childs Nerv Syst Volume: 32 Issue: 9 Pages: 1625-32
  • DOI: 10.1007/s00381-016-3160-9
  • NAID: 120005830643
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Prediction of postoperative diabetes insipidus using morphological hyperintensity patterns in the pituitary stalk on magnetic resonance imaging after transsphenoidal surgery for sellar tumors. (2016)
  • Author(s): Hayashi Y, Kita D, Watanabe T, Fukui I, Sasagawa Y, Oishi M, Tachibana O, Ueda F, Nakada M.
  • Journal Title: Pituitary Volume: 19 Issue: 6 Pages: 552-9
  • DOI: 10.1007/s11102-016-0739-9
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Diagnostic value of interleukin-10 in cerebrospinal fluid for diffuse large B-cell lymphoma of the central nervous system. (2015)
  • Author(s): Sasagawa Y, Akai T, Tachibana O, Iizuka H.
  • Journal Title: J Neurooncol Volume: 121 Issue: 1 Pages: 177-183
  • DOI: 10.1007/s11060-014-1622-z
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Median nerve conduction studies and wrist magnetic resonance imaging in acromegalic patients with carpal tunnel syndrome. (2015)
  • Author(s): Sasagawa Y, Tachibana O, Doai M, Tonami H, Iizuka H.
  • Journal Title: Pituitary Volume: 18 Issue: 5 Pages: 695-700
  • DOI: 10.1007/s11102-015-0642-9
  • Peer Reviewed
• [Journal Article] Pituitary apoplexy following gonadotropin-releasing hormone agonist administration with gonadotropin-secreting pituitary adenoma. (2015)
  • Author(s): Sasagawa Y, Tachibana O, Nakagawa A, Koya D, Iizuka H.
  • Journal Title: J Clin Neurosci Volume: 22 Issue: 3 Pages: 601-603
  • DOI: 10.1016/j.jocn.2014.08.015
  • Peer Reviewed
• [Journal Article] NAB2-STAT6 fusion gene analysis in two cases of meningeal solitary fibrous tumor/hemangiopericytoma with late distant metastases. (2015)
  • Author(s): Nakada S, Minato H, Takegami T, Kurose N, Ikeda H, Kobayashi M, Sasagawa Y, Akai T, Kato T, Yamamoto N, Nojima T.
  • Journal Title: Brain Tumor Pathol Volume: 32 Issue: 4 Pages: 268-274
  • DOI: 10.1007/s10014-015-0220-x
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 脳室内腫瘍における神経内視鏡下生検術とNarrow Band Imagingの利用 (2015)
  • Author(s): 笹川 泰生、赤井 卓也、中田 聡子、福井 一生、林 康彦、立花 修、野島 孝之、飯塚 秀明、中田 光俊
  • Organizer: 第22回日本神経内視鏡学会
  • Place of Presentation: ホテル松島大観荘（宮城県宮城郡）
  • Year and Date: 2015-11-05
• [Presentation] 脳実質内腫瘍に対する神経内視鏡下生検術の適応と限界 (2015)
  • Author(s): 笹川 泰生、赤井 卓也、林 康彦、飯塚 秀明、中田 光俊
  • Organizer: 第74回日本脳神経外科学会学術総会
  • Place of Presentation: ロイトン札幌（北海道札幌市）
  • Year and Date: 2015-10-14
• [Presentation] 脳実質内腫瘍に対するナビゲーション誘導内視鏡下生検術の安全性と課題 (2015)
  • Author(s): 笹川 泰生、赤井 卓也、林 康彦、飯塚 秀明、中田 光俊
  • Organizer: 第20回日本脳腫瘍の外科学会
  • Place of Presentation: 名古屋観光ホテル（愛知県名古屋市）
  • Year and Date: 2015-09-25
• [Presentation] 磁場式ナビゲーション支援による内視鏡下脳腫瘍生検術: 利点と工夫および今後の課題 (2015)
  • Author(s): 笹川 泰生、赤井 卓也、飯塚 秀明
  • Organizer: 第24回脳神経外科手術と機器学会
  • Place of Presentation: ナレッジキャピタル コングレコンベンションセンター（大阪府大阪市）
  • Year and Date: 2015-04-03