| Project/Area Number |
15K19982
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
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| Research Institution | Osaka Medical College |
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Principal Investigator |
Hiramatsu Ryo 大阪医科大学, 医学部, 助教 (40609707)
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| Research Collaborator |
M. Graça H. Vicente Louisiana State University, Department of Chemistry
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 悪性神経膠腫 / BNCT / PDT / ホウ素化ポルフィリン / CED / ホウ素化クロリン / ホウ素中性子捕捉療法 / 光線力学的療法 |
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| Outline of Final Research Achievements |
In this study, H2OCP as a novel boronated porphyrin has been proven to be a promising photosensitizer for PDT. H2OCP has also been proposed as a potentially effective replacement of BPA or BSH, or as a replacement of both BPA/BSH. This study provides more evidence that H2OCP could be an effective novel dual sensitizing agent for use in both PDT and BNCT. And Boronated chlorin as well as a boronated porphyrin is a large-ring compound and has a tumor affinity. So, boronated chlorin has also been proven to be a dual sensitizing agent for use in both PDT and BNCT. In this study, we also searched a useful drug for a dual sensitizing agent.
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