Investigation on mechanisms of action of deep brain stimulation therapy for Parkinson's disease using near infrared spectroscopy

• Project/Area Number: 15K19984
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: Fukuoka University
• Principal Investigator: Morishita Takashi 福岡大学, 医学部, 講師 (20750756)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: パーキンソン病 / 脳深部刺激療法 / 脳可塑性 / 脳神経活動 / NIRS / 光イメージング / ニューロモデュレーション / 機能的神経外科 / 脳神経機能回復

Outline of Final Research Achievements

In this study, we measured cortical activities in the brain of Parkinson's disease (PD) patients before and after deep brain stimulation (DBS) therapy using Near Infrared Spectroscopy (NIRS). Our NIRS study showed increased cortical activities as well as improvement of PD symptoms. This study sheds light on the mechanisms of DBS therapy for PD, and contributes to the development of new therapy.

Research Products

• [Journal Article] Biofeedback effect of hybrid assistive limb in stroke rehabilitation: A proof of concept study using functional near infrared spectroscopy (2018)
  • Author(s): Saita Kazuya、Morishita Takashi、Arima Hisatomi、Hyakutake Koichi、Ogata Toshiyasu、Yagi Kenji、Shiota Etsuji、Inoue Tooru
  • Journal Title: PLOS ONE Volume: 13 Issue: 1 Pages: e0191361-e0191361
  • DOI: 10.1371/journal.pone.0191361
  • Peer Reviewed / Open Access
• [Journal Article] Need for multiple biomarkers to adjust parameters of closed-loop deep brain stimulation for Parkinson's disease (2017)
  • Author(s): Morishita T, Inoue T
  • Journal Title: Neural Regeneration Research Volume: 12 Issue: 5 Pages: 747-748
  • DOI: 10.4103/1673-5374.206642
  • Peer Reviewed / Open Access
• [Journal Article] Delayed Onset Eye Opening Apraxia due to Progression of Brain Atrophy following Subthalamic Nucleus Deep Brain Stimulation: A Case Report (2017)
  • Author(s): Morishita, T. Higuchi, M. A. Tsuboi, Y. Samura, K. Inoue, T.
  • Journal Title: NMC Case Report Journal Volume: 4 Issue: 1 Pages: 1-3
  • DOI: 10.2176/nmccrj.cr.2016-0012
  • NAID: 130005239878
  • ISSN: 2188-4226
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Combined therapy using botulinum toxin A and single-joint hybrid assistive limb for upper-limb disability due to spastic hemiplegia (2017)
  • Author(s): Saita, K. Morishita (Corresponding Author), T. Hyakutake, K. Fukuda, H. Shiota, E. Sankai, Y. Inoue, T.
  • Journal Title: Journal of the Neurological Sciences Volume: 373 Pages: 182-187
  • DOI: 10.1016/j.jns.2016.12.056
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Contralateral Cerebral Hypometabolism After Cerebellar Stroke: A Functional Near-Infrared Spectroscopy Study (2017)
  • Author(s): Saita, K. Ogata, T. Watanabe, J. Tsuboi, Y. Takahara, M. Inoue, T. Morishita, T.
  • Journal Title: Journal of Stroke and Cerebrovascular Diseases Volume: 26 Issue: 4 Pages: e69-e71
  • DOI: 10.1016/j.jstrokecerebrovasdis.2017.01.014
  • Peer Reviewed
• [Journal Article] Changes in Motor-Related Cortical Activity Following Deep Brain Stimulation for Parkinson's Disease Detected by Functional Near Infrared Spectroscopy: A Pilot Study (2016)
  • Author(s): Morishita, T. Higuchi, M. A. Saita, K. Tsuboi, Y. Abe, H. Inoue, T.
  • Journal Title: Frontiers in Human Neuroscience Volume: 10 Pages: 629-629
  • DOI: 10.3389/fnhum.2016.00629
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Tailor-made Rehabilitation Approach Using Multiple Types of Hybrid Assistive Limb Robots for Acute Stroke Patients: A Pilot Study (2016)
  • Author(s): 5.Fukuda H, Morishita T (corresponding author), Ogata T, Saita K, Hyakutake K, Watanabe J, Shiota E, Inoue T
  • Journal Title: Assistive Technology Volume: 28 Issue: 1 Pages: 53-6
  • DOI: 10.1080/10400435.2015.1080768
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Interactive Bio-feedback Therapy Using Hybrid Assistive Limbs for Motor Recovery after Stroke: Current Practice and Future Perspectives (2016)
  • Author(s): Morishita, T. Inoue, T.
  • Journal Title: Neurologia medico-chirurgica Volume: 56 Issue: 10 Pages: 605-612
  • DOI: 10.2176/nmc.st.2016-0094
  • NAID: 130005429956
  • ISSN: 0470-8105, 1349-8029
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Brain Stimulation Therapy for Central Post-Stroke Pain from a Perspective of Interhemispheric Neural Network Remodeling (2016)
  • Author(s): Morishita T and Inoue T
  • Journal Title: Frontiers in Human Neuroscience Volume: 10 Pages: 166-166
  • DOI: 10.3389/fnhum.2016.00166
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Extracranial and Intracranial Vertebral Artery Dissections: A Comparison of Diagnostic Features (2016)
  • Author(s): Kobayashi H, Morishita T (corresponding author), Ogata T, Matsumoto J, Okawa M, Higashi T, Inoue T
  • Journal Title: Journal of the Neurological Sciences Volume: 362 Pages: 244-50
  • DOI: 10.1016/j.jns.2016.01.062
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Delayed Onset Eye Opening Apraxia due to Progression of Brain Atrophy following Subthalamic Nucleus Deep Brain Stimulation: A Case Report (2016)
  • Author(s): Morishita T, Higuchi M, Tsuboi Y, Samura K, Inoue T
  • Journal Title: NMC Case Report Journal Volume: 印刷中
  • NAID: 130005239878
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Is One Large Target Better Thank Two? (2015)
  • Author(s): Morishita T, Tsuboi Y, Higuchi M, Inoue T
  • Journal Title: Journal of Neurosurgery Volume: 123 Issue: 5 Pages: 1349-1349
  • DOI: 10.3171/2015.4.jns15850
  • Peer Reviewed
• [Journal Article] Pain Reduction Associated with Improved Functional Interhemispheric Balance Following Transcranial Direct Current Stimulation for Post-Stroke Central Pain: A Case Study (2015)
  • Author(s): Morishita T, Hyakutake K, Saita K, Takahara M, Shiota E, Inoue T
  • Journal Title: Journal of the Neurological Sciences Volume: 358 Issue: 1-2 Pages: 484-5
  • DOI: 10.1016/j.jns.2015.08.1551
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 多チャンネル型NIRSを用いたパーキンソン病に対する脳深部刺激による運動関連脳活動変化の計測 (2017)
  • Author(s): 森下登史, 樋口正晃, 斉田和哉, 坪井義夫, 安部洋, 井上亨
  • Organizer: 第56回 日本定位・機能神経外科学会
  • Place of Presentation: コングレコンベンションセンター 大阪
  • Year and Date: 2017-01-27
• [Presentation] 脳卒中慢性期運動麻痺に対する経頭蓋直流電気刺激療法を併用したリハビリテーションの効果 (2017)
  • Author(s): 森下 登史, 百武 光一, 斉田 和哉, 高原 正樹, 塩田 悦仁, 井上 亨
  • Organizer: 第56回 日本定位・機能神経外科学会
  • Place of Presentation: コングレコンベンションセンター 大阪
  • Year and Date: 2017-01-27
• [Presentation] Dynamic Motor-related Cortical Activity Following Deep Brain Stimulation for Parkinson's Disease: A Functional Near Infrared Spectroscopy Study (2017)
  • Author(s): Takashi Morishita, M.D., Ph.D.,1 Masa-aki Higuchi, M.D., Ph.D.,2 Kazuya Saita, O.T.,1,3 Yoshio Tsuboi, M.D., Ph.D.,2 Hiroshi Abe, M.D., Ph.D., 1 Shogo Yamada, Hiroshi Muratani, Tooru Inoue.
  • Organizer: INS 13th World Congress
  • Int'l Joint Research
• [Presentation] パーキンソン病患者に対する片側脳深部刺激の効果と安全性 (2016)
  • Author(s): 森下 登史, 樋口 正晃, 左村 和宏, 坪井 義夫, 井上 亨
  • Organizer: 日本脳神経外科学会第75回学術総会
  • Place of Presentation: 福岡国際会議場 福岡
  • Year and Date: 2016-09-29
• [Presentation] 脳卒中慢性期運動機能障害に対する経頭蓋直流電気刺激療法を併用したリハビリテーションの効果 (2016)
  • Author(s): 森下 登史, 百武 光一, 斉田 和哉, 高原 正樹, 塩田 悦仁, 井上 亨
  • Organizer: 第30回 日本ニューロモデュレーション学会
  • Place of Presentation: 都市センターホテル（東京都千代田区）
  • Year and Date: 2016-05-07
• [Presentation] 視床下核刺激による非運動症状出現と解剖学的電極埋設部位との関係 (2016)
  • Author(s): 森下 登史, 樋口 正晃, 坪井 義夫, 左村 和宏, 井上 亨
  • Organizer: 第５５回日本定位・機能神経外科学会
  • Place of Presentation: 江陽グランドホテル（宮城県仙台市）
  • Year and Date: 2016-01-23
• [Presentation] 運動機能における半球間バランスから見た脳卒中後中枢性疼痛に対する経頭蓋直流電気刺激療法の効果 (2016)
  • Author(s): 森下 登史, 百武 光一, 斉田 和哉, 高原 正樹, 塩田 悦仁, 井上 亨
  • Organizer: 第５５回日本定位・機能神経外科学会
  • Place of Presentation: 江陽グランドホテル（宮城県仙台市）
  • Year and Date: 2016-01-23
• [Presentation] 脳卒中慢性期運動機能障害に対する経頭蓋直流電気刺激療法を併用したリハビリテーションの効果 (2016)
  • Author(s): 森下 登史, 百武 光一, 斉田 和哉, 高原 正樹, 塩田 悦仁, 井上 亨
  • Organizer: 第30回 日本ニューロモデュレーション学会
  • Place of Presentation: 都市センターホテル 東京
• [Remarks] 福岡大学医学部脳神経外科 脳神経機能回復に関する研究と治療の紹介
  • URL: http://www.fu-functionalrecovery.com/work.html