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Investigation on mechanisms of action of deep brain stimulation therapy for Parkinson's disease using near infrared spectroscopy

Research Project

Project/Area Number 15K19984
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurosurgery
Research InstitutionFukuoka University

Principal Investigator

Morishita Takashi  福岡大学, 医学部, 講師 (20750756)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsパーキンソン病 / 脳深部刺激療法 / 脳可塑性 / 脳神経活動 / NIRS / 光イメージング / ニューロモデュレーション / 機能的神経外科 / 脳神経機能回復
Outline of Final Research Achievements

In this study, we measured cortical activities in the brain of Parkinson's disease (PD) patients before and after deep brain stimulation (DBS) therapy using Near Infrared Spectroscopy (NIRS). Our NIRS study showed increased cortical activities as well as improvement of PD symptoms. This study sheds light on the mechanisms of DBS therapy for PD, and contributes to the development of new therapy.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (22 results)

All 2018 2017 2016 2015 Other

All Journal Article (13 results) (of which Peer Reviewed: 13 results,  Open Access: 6 results,  Acknowledgement Compliant: 9 results) Presentation (8 results) (of which Int'l Joint Research: 1 results) Remarks (1 results)

  • [Journal Article] Biofeedback effect of hybrid assistive limb in stroke rehabilitation: A proof of concept study using functional near infrared spectroscopy2018

    • Author(s)
      Saita Kazuya、Morishita Takashi、Arima Hisatomi、Hyakutake Koichi、Ogata Toshiyasu、Yagi Kenji、Shiota Etsuji、Inoue Tooru
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 1 Pages: e0191361-e0191361

    • DOI

      10.1371/journal.pone.0191361

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Need for multiple biomarkers to adjust parameters of closed-loop deep brain stimulation for Parkinson's disease2017

    • Author(s)
      Morishita T, Inoue T
    • Journal Title

      Neural Regeneration Research

      Volume: 12 Issue: 5 Pages: 747-748

    • DOI

      10.4103/1673-5374.206642

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Delayed Onset Eye Opening Apraxia due to Progression of Brain Atrophy following Subthalamic Nucleus Deep Brain Stimulation: A Case Report2017

    • Author(s)
      Morishita, T. Higuchi, M. A. Tsuboi, Y. Samura, K. Inoue, T.
    • Journal Title

      NMC Case Report Journal

      Volume: 4 Issue: 1 Pages: 1-3

    • DOI

      10.2176/nmccrj.cr.2016-0012

    • NAID

      130005239878

    • ISSN
      2188-4226
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Combined therapy using botulinum toxin A and single-joint hybrid assistive limb for upper-limb disability due to spastic hemiplegia2017

    • Author(s)
      Saita, K. Morishita (Corresponding Author), T. Hyakutake, K. Fukuda, H. Shiota, E. Sankai, Y. Inoue, T.
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 373 Pages: 182-187

    • DOI

      10.1016/j.jns.2016.12.056

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Contralateral Cerebral Hypometabolism After Cerebellar Stroke: A Functional Near-Infrared Spectroscopy Study2017

    • Author(s)
      Saita, K. Ogata, T. Watanabe, J. Tsuboi, Y. Takahara, M. Inoue, T. Morishita, T.
    • Journal Title

      Journal of Stroke and Cerebrovascular Diseases

      Volume: 26 Issue: 4 Pages: e69-e71

    • DOI

      10.1016/j.jstrokecerebrovasdis.2017.01.014

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Changes in Motor-Related Cortical Activity Following Deep Brain Stimulation for Parkinson's Disease Detected by Functional Near Infrared Spectroscopy: A Pilot Study2016

    • Author(s)
      Morishita, T. Higuchi, M. A. Saita, K. Tsuboi, Y. Abe, H. Inoue, T.
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 10 Pages: 629-629

    • DOI

      10.3389/fnhum.2016.00629

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Tailor-made Rehabilitation Approach Using Multiple Types of Hybrid Assistive Limb Robots for Acute Stroke Patients: A Pilot Study2016

    • Author(s)
      5.Fukuda H, Morishita T (corresponding author), Ogata T, Saita K, Hyakutake K, Watanabe J, Shiota E, Inoue T
    • Journal Title

      Assistive Technology

      Volume: 28 Issue: 1 Pages: 53-6

    • DOI

      10.1080/10400435.2015.1080768

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Interactive Bio-feedback Therapy Using Hybrid Assistive Limbs for Motor Recovery after Stroke: Current Practice and Future Perspectives2016

    • Author(s)
      Morishita, T. Inoue, T.
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 56 Issue: 10 Pages: 605-612

    • DOI

      10.2176/nmc.st.2016-0094

    • NAID

      130005429956

    • ISSN
      0470-8105, 1349-8029
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Brain Stimulation Therapy for Central Post-Stroke Pain from a Perspective of Interhemispheric Neural Network Remodeling2016

    • Author(s)
      Morishita T and Inoue T
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 10 Pages: 166-166

    • DOI

      10.3389/fnhum.2016.00166

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Extracranial and Intracranial Vertebral Artery Dissections: A Comparison of Diagnostic Features2016

    • Author(s)
      Kobayashi H, Morishita T (corresponding author), Ogata T, Matsumoto J, Okawa M, Higashi T, Inoue T
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 362 Pages: 244-50

    • DOI

      10.1016/j.jns.2016.01.062

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Delayed Onset Eye Opening Apraxia due to Progression of Brain Atrophy following Subthalamic Nucleus Deep Brain Stimulation: A Case Report2016

    • Author(s)
      Morishita T, Higuchi M, Tsuboi Y, Samura K, Inoue T
    • Journal Title

      NMC Case Report Journal

      Volume: 印刷中

    • NAID

      130005239878

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Is One Large Target Better Thank Two?2015

    • Author(s)
      Morishita T, Tsuboi Y, Higuchi M, Inoue T
    • Journal Title

      Journal of Neurosurgery

      Volume: 123 Issue: 5 Pages: 1349-1349

    • DOI

      10.3171/2015.4.jns15850

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pain Reduction Associated with Improved Functional Interhemispheric Balance Following Transcranial Direct Current Stimulation for Post-Stroke Central Pain: A Case Study2015

    • Author(s)
      Morishita T, Hyakutake K, Saita K, Takahara M, Shiota E, Inoue T
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 358 Issue: 1-2 Pages: 484-5

    • DOI

      10.1016/j.jns.2015.08.1551

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 多チャンネル型NIRSを用いたパーキンソン病に対する脳深部刺激による運動関連脳活動変化の計測2017

    • Author(s)
      森下登史, 樋口正晃, 斉田和哉, 坪井義夫, 安部洋, 井上亨
    • Organizer
      第56回 日本定位・機能神経外科学会
    • Place of Presentation
      コングレコンベンションセンター 大阪
    • Year and Date
      2017-01-27
    • Related Report
      2016 Research-status Report
  • [Presentation] 脳卒中慢性期運動麻痺に対する経頭蓋直流電気刺激療法を併用したリハビリテーションの効果2017

    • Author(s)
      森下 登史, 百武 光一, 斉田 和哉, 高原 正樹, 塩田 悦仁, 井上 亨
    • Organizer
      第56回 日本定位・機能神経外科学会
    • Place of Presentation
      コングレコンベンションセンター 大阪
    • Year and Date
      2017-01-27
    • Related Report
      2016 Research-status Report
  • [Presentation] Dynamic Motor-related Cortical Activity Following Deep Brain Stimulation for Parkinson's Disease: A Functional Near Infrared Spectroscopy Study2017

    • Author(s)
      Takashi Morishita, M.D., Ph.D.,1 Masa-aki Higuchi, M.D., Ph.D.,2 Kazuya Saita, O.T.,1,3 Yoshio Tsuboi, M.D., Ph.D.,2 Hiroshi Abe, M.D., Ph.D., 1 Shogo Yamada, Hiroshi Muratani, Tooru Inoue.
    • Organizer
      INS 13th World Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] パーキンソン病患者に対する片側脳深部刺激の効果と安全性2016

    • Author(s)
      森下 登史, 樋口 正晃, 左村 和宏, 坪井 義夫, 井上 亨
    • Organizer
      日本脳神経外科学会第75回学術総会
    • Place of Presentation
      福岡国際会議場 福岡
    • Year and Date
      2016-09-29
    • Related Report
      2016 Research-status Report
  • [Presentation] 脳卒中慢性期運動機能障害に対する経頭蓋直流電気刺激療法を併用したリハビリテーションの効果2016

    • Author(s)
      森下 登史, 百武 光一, 斉田 和哉, 高原 正樹, 塩田 悦仁, 井上 亨
    • Organizer
      第30回 日本ニューロモデュレーション学会
    • Place of Presentation
      都市センターホテル(東京都千代田区)
    • Year and Date
      2016-05-07
    • Related Report
      2015 Research-status Report
  • [Presentation] 視床下核刺激による非運動症状出現と解剖学的電極埋設部位との関係2016

    • Author(s)
      森下 登史, 樋口 正晃, 坪井 義夫, 左村 和宏, 井上 亨
    • Organizer
      第55回日本定位・機能神経外科学会
    • Place of Presentation
      江陽グランドホテル(宮城県仙台市)
    • Year and Date
      2016-01-23
    • Related Report
      2015 Research-status Report
  • [Presentation] 運動機能における半球間バランスから見た脳卒中後中枢性疼痛に対する経頭蓋直流電気刺激療法の効果2016

    • Author(s)
      森下 登史, 百武 光一, 斉田 和哉, 高原 正樹, 塩田 悦仁, 井上 亨
    • Organizer
      第55回日本定位・機能神経外科学会
    • Place of Presentation
      江陽グランドホテル(宮城県仙台市)
    • Year and Date
      2016-01-23
    • Related Report
      2015 Research-status Report
  • [Presentation] 脳卒中慢性期運動機能障害に対する経頭蓋直流電気刺激療法を併用したリハビリテーションの効果2016

    • Author(s)
      森下 登史, 百武 光一, 斉田 和哉, 高原 正樹, 塩田 悦仁, 井上 亨
    • Organizer
      第30回 日本ニューロモデュレーション学会
    • Place of Presentation
      都市センターホテル 東京
    • Related Report
      2016 Research-status Report
  • [Remarks] 福岡大学医学部脳神経外科 脳神経機能回復に関する研究と治療の紹介

    • URL

      http://www.fu-functionalrecovery.com/work.html

    • Related Report
      2017 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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