| Project/Area Number |
15K19994
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Osaka University |
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Principal Investigator |
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| Research Collaborator |
Kaito Takashi 大阪大学, 大学院医学系研究科・器官制御外科学(整形外科), 助教
Takenaka Shota 大阪大学, 大学院医学系研究科・器官制御外科学(整形外科), 助教
Sakai Yusuke 大阪大学, 医学部附属病院・リハビリテーション科, 医員
Yoshikawa Hideki 大阪大学, 理事・副学長
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 思春期特発性側弯症 / 三次元 / 骨形態 / 椎体 / 非対称性 / CT / 可逆性 |
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| Outline of Final Research Achievements |
Our researches were aimed to reveal the mechanism of vertebral body deformities in patients with adolescent idiopathic scoliosis (AIS) by in vivo three-dimensional morphometric analysis. The appearance rates of the ossification center in the epiphyseal ring were lower at the concave side than at the convex side, except in the end vertebrae in AIS patients. This difference was more apparent around the apical vertebrae. The wedge deformity of vertebral bodies showed a reshaping potential towards a symmetrical configuration in the region other than end and apex, although no plasticity of the vertebrae was observed in the apical region even in skeletally immature patients with AIS. When compared to the wedging of the vertebral bodies around apical vertebrae in the major curve in neuromuscular scoliosis, which was caused by asymmetric loading, the wedge deformities in both the main and compensatory curves in AIS were more severe than would be expected.
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