| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
It has been reported that dysfunction of osteoclasts and dendritic cells occurs in rheumatoid arthritis(RA). However, it remains unclear whether function of endoplasmic reticulum (ER) in osteoclasts and dendritic cells is involved in pathogenesis of RA. In this study, analysis of mouse model for RA using conditional knockout mouse of ER-resident transcription factor Luman has been performed. Although in vivo investigation by RA mouse model was not able to obtain a concrete answer, in vitro investigation has revealed that Luman deficient dendritic cells attenuate the antigen-presenting ability, compared with wild type dendritic cells.
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