Role of Endoplasmic reticulum stress response in rheumatoid arthritis
| Project/Area Number |
15K20001
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
Kanemoto Soshi 広島大学, 医歯薬保健学研究院(医), 講師 (90611913)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 関節リウマチ / 小胞体ストレス / 破骨細胞 / 樹状細胞 / 小胞体膜局在転写因子 |
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| Outline of Final Research Achievements |
It has been reported that dysfunction of osteoclasts and dendritic cells occurs in rheumatoid arthritis(RA). However, it remains unclear whether function of endoplasmic reticulum (ER) in osteoclasts and dendritic cells is involved in pathogenesis of RA. In this study, analysis of mouse model for RA using conditional knockout mouse of ER-resident transcription factor Luman has been performed. Although in vivo investigation by RA mouse model was not able to obtain a concrete answer, in vitro investigation has revealed that Luman deficient dendritic cells attenuate the antigen-presenting ability, compared with wild type dendritic cells.
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] Genome-wide identification and gene expression profiling of ubiquitin ligases for endoplasmic reticulum protein degradation2016
Author(s)
Kaneko M, Iwase I, Yamasaki Y, Takai T, Wu Y, Kanemoto S, Matsuhisa K, Asada R, Okuma Y, Watanabe T, Imaizumi K, Nomura Y.
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Journal Title
Scientific reports
Volume: 6
Issue: 1
Pages: 30955-30955
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Luman is involved in osteoclastogenesis through the regulation of DC-STAMP expression, stability and localization.2015
Author(s)
Kanemoto S, Kobayashi Y, Yamashita T, Miyamoto T, Cui M, Asada R, Cui X, Hino K, Kaneko M, Takai T, Matsuhisa K, Takahashi N, Imaizumi K.
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Journal Title
J Cell Sci
Volume: 128
Pages: 4353-4365
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Promotion of cancer cell proliferation by cleaved and secreted luminal domains of ER stress transducer BBF2H7.2015
Author(s)
Iwamoto H, Matsuhisa K, Saito A, Kanemoto S, Asada R, Hino K, Takai T, Cui M, Cui X, Kaneko M, Arihiro K, Sugiyama K, Kurisu K, Matsubara A, Imaizumi K.
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Journal Title
Plos One
Volume: 10
Issue: 5
Pages: 1-17
DOI
Related Report
Peer Reviewed / Open Access
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