| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The ligamentum flavum with hypertrophy had lower elastin contents and higher collagen contents than that without hypertrophy. The expression of gene markers for extracellular matrix fibrosis significantly increased, such as transforming growth factor-beta-1, α-smooth muscle actin, connective tissue growth factor, Angiopoietin-like protein 2 (Angptl2) and tissue inhibitor of matrix metalloproteinases-2 (TIMP-2). Angptl2 and TIMP-2 concentration was significantly higher in the dorsal side of the ligamentum flavum than in the ventral side the ligamentum flavum. The increased expression of TGF-β1 related gene from hypertrophy of the ligamentum flavum might induce fibrotic thickening in the ligamentum flavum for lumbar spinal canal stenosis. The increased expression of Angptl2 and TIMP-2 in the dorsal side of ligamentum flavum may play an important role of fibrosis and hypertrophy of the ligamentum flavum.
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